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PMID: 10903566 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats.

Nature neuroscience ·Vol. 3 ·No. 8 ·2000-08-00 ·Pages 757-8

Spanswick D, Smith MA, Mirshamsi S, Routh VH, Ashford ML

Abstract

Insulin and leptin receptors are present in hypothalamic regions that control energy homeostasis, and these hormones reduce food intake and body weight in lean, but not obese, Zucker rats. Here we demonstrate that insulin, like leptin, hyperpolarizes lean rat hypothalamic glucose-responsive (GR) neurons by opening KATP channels. These findings suggest hypothalamic K ATP channel function is crucial to physiological regulation of food intake and body weight.

MeSH Terms

Adenosine Triphosphate/pharmacology Animals Arcuate Nucleus of Hypothalamus/physiology Glucose/pharmacology Hypothalamus/physiology,physiopathology In Vitro Techniques Insulin/pharmacology Leptin/pharmacology Membrane Potentials/drug effects Neurons/physiology Obesity/genetics,physiopathology Patch-Clamp Techniques Phosphatidylinositol 3-Kinases/metabolism Potassium Channels/drug effects,physiology Rats Rats, Zucker Thinness Tolbutamide/pharmacology

Chemicals

Insulin Leptin Potassium Channels Adenosine Triphosphate Tolbutamide Phosphatidylinositol 3-Kinases Glucose

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Spanswick D

Department of Biomedical Sciences, University of Aberdeen, Aberdeen Centre for Energy Regulation and Obesity, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK.

Smith M A

Mirshamsi S

Routh V H

Ashford M L

Article Info

Journal

Nature neuroscience

Abbr.

Nat Neurosci

ISSN

1097-6256

DOI

10.1038/77660

Published

2000-08-00

Pages

757-8

Language

English

Region

United States

NLM ID

9809671

Subset

External Links

PubMed source DOI: 10.1038/77660 View journal details

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Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats.

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