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PMID: 10881687 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Comparison of proviral accessory genes between long-term nonprogressors and progressors of human immunodeficiency virus type 1 infection.

Archives of virology ·Vol. 145 ·No. 5 ·2000-00-00 ·Pages 1021-7

Yamada T, Iwamoto A

Abstract

We compared proviral accessory gene sequences (nef, vpu, vpr, vif, rev, tat) of human immunodeficiency virus type 1 (HIV-1) in the peripheral blood mononuclear cells (PBMC) between seven long-term non-progressors (LTNP) and seven progressors. LTNP frequently harbored proviruses with mutated accessory genes, while almost all accessory genes were intact in progressors. Presence of quasispecies in attenuated viruses suggests that they were not just a fossil record of nonreplication proviruses. These attenuated viruses in LTNP may be the source of their strong immune response against HIV-1. Our result might have relevance to a design of potent therapeutic vaccines.

MeSH Terms
AIDS Vaccines/immunology Genes, Viral HIV Infections/immunology,virology HIV Long-Term Survivors HIV-1/genetics,immunology,pathogenicity Humans Leukocytes, Mononuclear/virology Male Molecular Sequence Data Mutation Proviruses/genetics,immunology Virulence/genetics
Chemicals
AIDS Vaccines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Yamada T
Department of Infectious Diseases, University of Tokyo, Japan.
Iwamoto A
Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
DOI
10.1007/s007050050692
Published
2000-00-00
Pages
1021-7
Language
English
Region
Austria
NLM ID
7506870
Subset
IM
Databases
GENBANK
AB034252, AB034253, AB034254, AB034255, AB034256, AB034257, AB034258, AB034259, AB034260, AB034261, AB034262, AB034263, AB034264, AB034265, AB034266, AB034267, AB034268, AB034269, AB034270, AB034271, AB034272, AB034273, AB034274, AB034275, AB034276, AB034277, AB034278, AB034279, AB034280, AB034281
External Links
PubMed source DOI: 10.1007/s007050050692 View journal details
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