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PMID: 10878813 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

Nature cell biology ·Vol. 2 ·No. 7 ·2000-07-00 ·Pages 461-2

Herreman A, Serneels L, Annaert W, Collen D, Schoonjans L, De Strooper B

Abstract

暂无摘要

MeSH Terms

Alzheimer Disease/enzymology Amyloid Precursor Protein Secretases Amyloid beta-Protein Precursor/genetics,metabolism Animals Aspartic Acid Endopeptidases Endopeptidases/metabolism Enzyme Activation Membrane Proteins/deficiency,genetics,physiology Mice Mice, Knockout Mutation Presenilin-1 Presenilin-2 Stem Cells/enzymology,metabolism

Chemicals

Amyloid beta-Protein Precursor Membrane Proteins Presenilin-1 Presenilin-2 Amyloid Precursor Protein Secretases Endopeptidases Aspartic Acid Endopeptidases Bace1 protein, mouse

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Herreman A

Neuronal Cell Biology Laboratory, CME, K.U.Leuven and Flanders Interuniversitary Institute for Biotechnology (VIB4), Belgium.

Serneels L

Annaert W

Collen D

Schoonjans L

De Strooper B

Article Info

Journal

Nature cell biology

Abbr.

Nat Cell Biol

ISSN

1465-7392

DOI

10.1038/35017105

Published

2000-07-00

Pages

461-2

Language

English

Region

England

NLM ID

100890575

Subset

External Links

PubMed source DOI: 10.1038/35017105 View journal details

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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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