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PMID: 10878809 Published · ppublish English Journal Article

Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B.

Nature cell biology ·Vol. 2 ·No. 7 ·2000-07-00 ·Pages 435-40

Katagiri Y, Takeda K, Yu ZX, Ferrans VJ, Ozato K, Guroff G

Abstract

The retinoid-X receptor (RXR) regulates multiple hormonal pathways through heterodimerization with nuclear receptors such as the all-trans retinoic acid receptor (RAR). The orphan nuclear receptor NGFI-B (also called Nur77) can heterodimerize with RXR. Here we show that nerve growth factor (NGF) induces the phosphorylation of Ser 105 of NGFI-B in PC12 phaeochromocytoma cells, resulting in translocation of the NGFI-B-RXR heterodimer complex out of the nucleus using nuclear export signals within NGFI-B. As a consequence of the redistribution of RXR, the transcriptional activity of RXR-RAR is reduced. NGFI-B-mediated nuclear export of receptors may serve as a mechanism for crosstalk between NGF and retinoid pathways.

MeSH Terms
Amino Acid Sequence Animals Binding Sites Biological Transport/drug effects Cell Nucleus/drug effects,metabolism Cytoplasm/drug effects,enzymology,metabolism DNA/genetics,metabolism DNA-Binding Proteins/chemistry,genetics,metabolism Dimerization Gene Expression Regulation/drug effects Ligands MAP Kinase Signaling System/drug effects Mutation Nerve Growth Factor/pharmacology Nuclear Localization Signals Nuclear Receptor Subfamily 4, Group A, Member 1 PC12 Cells Phosphorylation/drug effects Phosphoserine/metabolism Protein Structure, Tertiary Rats Receptor Cross-Talk/drug effects Receptor Protein-Tyrosine Kinases/metabolism Receptors, Cytoplasmic and Nuclear Receptors, Retinoic Acid/genetics,metabolism Receptors, Steroid Recombinant Fusion Proteins/genetics,metabolism Retinoid X Receptors Retinoids/pharmacology Transcription Factors/chemistry,genetics,metabolism ras Proteins/metabolism
Chemicals
DNA-Binding Proteins Ligands Nr4a1 protein, rat Nuclear Localization Signals Nuclear Receptor Subfamily 4, Group A, Member 1 Receptors, Cytoplasmic and Nuclear Receptors, Retinoic Acid Receptors, Steroid Recombinant Fusion Proteins Retinoid X Receptors Retinoids Transcription Factors Phosphoserine DNA Nerve Growth Factor Receptor Protein-Tyrosine Kinases ras Proteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Katagiri Y
Section on Growth Factors, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA. katagiriy@usa.redcross.org
Takeda K
Yu Z X
Ferrans V J
Ozato K
Guroff G
Article Info
Journal
Nature cell biology
Abbr.
Nat Cell Biol
ISSN
1465-7392
Published
2000-07-00
Pages
435-40
Language
English
Region
England
NLM ID
100890575
Subset
IM
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