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PMID: 10861010 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 97 ·No. 13 ·2000-06-20 ·Pages 7446-51

Kipnis J, Yoles E, Porat Z, Cohen A, Mor F, Sela M, Cohen IR, Schwartz M

Abstract

We recently reported that the posttraumatic spread of degeneration in the damaged optic nerve can be attenuated by the adoptive transfer of autoimmune T cells specific to myelin basic protein. However, it would be desirable to obtain immune neuroprotection free of any possible autoimmune disease. In an attempt to obtain disease-free immune neuroprotection, we used the synthetic four-amino acid polymer copolymer 1 (Cop-1), which is known not to be encephalitogenic despite its cross-reactivity with myelin basic protein. We show here that active immunization with Cop-1 administered in adjuvant, as well as adoptive transfer of T cells reactive to Cop-1, can inhibit the progression of secondary degeneration after crush injury of the rat optic nerve. These results have implications for the treatment of optic neuropathies.

MeSH Terms
Animals Antigen Presentation Female Glatiramer Acetate Immunity, Cellular Immunotherapy, Adoptive Optic Nerve/immunology,pathology Optic Nerve Diseases/immunology,therapy Peptides/administration & dosage,immunology Rats Rats, Inbred Lew T-Lymphocytes/immunology
Chemicals
Peptides Glatiramer Acetate
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Kipnis J
Departments of Neurobiology and Immunology, The Weizmann Institute of Science, 76100 Rehovot, Israel.
Yoles E
Porat Z
Cohen A
Mor F
Sela M
Cohen I R
Schwartz M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.97.13.7446
Published
2000-06-20
Pages
7446-51
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC16565
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.97.13.7446 PMC Full Text View journal details
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