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PMID: 10852111 Published · ppublish English Journal Article Review

Regulation of cell function by Rho family GTPases.

Immunologic research ·Vol. 21 ·No. 2-3 ·2000-00-00 ·Pages 139-48

Bokoch GM

Abstract

Rho GTPases act as molecular switches to control many basic cellular activities that are also critical to the specialized functions of phagocytic leukocytes. Our laboratory has studied the regulation of Rho GTPase function, how these GTPases interact with specific effectors to modulate cell function, and how these events are coordinated in the stimulated cell. Areas of major interest include NADPH oxidase regulation by Rac2, Rac- and Cdc42-mediated control of the actin-myosin cytoskeleton via p21-activated kinase (PAK), and modulation of the apoptotic program by Rho GTPases and PAK.

MeSH Terms
Animals Apoptosis/physiology Cell Movement/physiology Cytoskeleton/physiology Humans Signal Transduction rho GTP-Binding Proteins/physiology
Chemicals
rho GTP-Binding Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Bokoch G M
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA. bokoch@scripps.edu
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Article Info
Journal
Immunologic research
Abbr.
Immunol Res
ISSN
0257-277X
DOI
10.1385/IR:21:2-3:139
Email
bokoch@scripps.edu
Published
2000-00-00
Pages
139-48
Language
English
Region
United States
NLM ID
8611087
Subset
IM
External Links
PubMed source DOI: 10.1385/IR:21:2-3:139 View journal details
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