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PMID: 10848603 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Role of DBP in the circadian oscillatory mechanism.

Molecular and cellular biology ·Vol. 20 ·No. 13 ·2000-07-00 ·Pages 4773-81

Yamaguchi S, Mitsui S, Yan L, Yagita K, Miyake S, Okamura H

Abstract

Transcript levels of DBP, a member of the PAR leucine zipper transcription factor family, exhibit a robust rhythm in suprachiasmatic nuclei, the mammalian circadian center. Here we report that DBP is able to activate the promoter of a putative clock oscillating gene, mPer1, by directly binding to the mPer1 promoter. The mPer1 promoter is cooperatively activated by DBP and CLOCK-BMAL1. On the other hand, dbp transcription is activated by CLOCK-BMAL1 through E-boxes and inhibited by the mPER and mCRY proteins, as is the case for mPer1. Thus, a clock-controlled dbp gene may play an important role in central clock oscillation.

MeSH Terms
ARNTL Transcription Factors Animals Base Sequence Basic Helix-Loop-Helix Transcription Factors Binding Sites CLOCK Proteins Cell Cycle Proteins Circadian Rhythm/genetics Cryptochromes DNA-Binding Proteins Drosophila Proteins Eye Proteins Flavoproteins/genetics,metabolism Gene Expression Regulation Male Mice Mice, Inbred BALB C Molecular Sequence Data Nuclear Proteins/genetics,metabolism Period Circadian Proteins Photoreceptor Cells, Invertebrate Promoter Regions, Genetic Receptors, G-Protein-Coupled Suprachiasmatic Nucleus/metabolism Trans-Activators/genetics,metabolism Transcription Factors/genetics,metabolism
Chemicals
ARNTL Transcription Factors Arntl protein, mouse Basic Helix-Loop-Helix Transcription Factors Cell Cycle Proteins Cryptochromes DNA-Binding Proteins Dbp protein, mouse Drosophila Proteins Eye Proteins Flavoproteins Nuclear Proteins Per1 protein, mouse Per3 protein, mouse Period Circadian Proteins Receptors, G-Protein-Coupled Trans-Activators Transcription Factors cry protein, Drosophila CLOCK Proteins Clock protein, mouse
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Yamaguchi S
Department of Anatomy and Brain Science, Kobe University School of Medicine, Japan.
Mitsui S
Yan L
Yagita K
Miyake S
Okamura H
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/MCB.20.13.4773-4781.2000
Published
2000-07-00
Pages
4773-81
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC85912
Subset
IM
External Links
PubMed source DOI: 10.1128/MCB.20.13.4773-4781.2000 PMC Full Text View journal details
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