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PMID: 10846112 Published · ppublish English Journal Article

Respiratory syncytial virus G and/or SH glycoproteins modify CC and CXC chemokine mRNA expression in the BALB/c mouse.

Journal of virology ·Vol. 74 ·No. 13 ·2000-07-00 ·Pages 6227-9

Tripp RA, Jones L, Anderson LJ

Abstract

Chemokine mRNA expression by pulmonary leukocytes following infection of BALB/c mice with two strains of respiratory syncytial virus (RSV) and one strain of parainfluenza virus type 3 (PIV-3) was determined. The results suggest that RSV G and/or SH proteins inhibit early MIP-1alpha, MIP-1beta, MIP-2, MCP-1, and IP-10 mRNA expression. TCA-3 mRNA expression was found to be increased during PIV-3 infection.

MeSH Terms
Animals Chemokine CCL1 Chemokine CCL2/genetics Chemokine CCL3 Chemokine CCL4 Chemokine CCL5/genetics Chemokine CXCL10 Chemokine CXCL2 Chemokines, CC/genetics Chemokines, CXC/genetics Cytokines/genetics Female Gene Expression Regulation Glycoproteins/genetics,metabolism HN Protein Macrophage Inflammatory Proteins/genetics Mice Mice, Inbred BALB C Monokines/genetics Parainfluenza Virus 3, Human/metabolism,physiology RNA, Messenger Receptors, CCR8 Respiratory Syncytial Virus, Human/genetics,metabolism Viral Envelope Proteins Viral Proteins/genetics,metabolism
Chemicals
CCL1 protein, human Ccr8 protein, mouse Chemokine CCL1 Chemokine CCL2 Chemokine CCL3 Chemokine CCL4 Chemokine CCL5 Chemokine CXCL10 Chemokine CXCL2 Chemokines, CC Chemokines, CXC Cytokines Glycoproteins HN Protein Macrophage Inflammatory Proteins Monokines RNA, Messenger Receptors, CCR8 Viral Envelope Proteins Viral Proteins attachment protein G
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tripp R A
Division of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. rgt3@cdc.gov
Jones L
Anderson L J
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/jvi.74.13.6227-6229.2000
Email
rgt3@cdc.gov
Published
2000-07-00
Pages
6227-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC112127
Subset
IM
External Links
PubMed source DOI: 10.1128/jvi.74.13.6227-6229.2000 PMC Full Text View journal details
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