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PMID: 1084423 Published · ppublish English Journal Article

X-linked recessive type of pure spastic paraplegia in a large pedigree: absence of detectable linkage with Xg.

Journal of medical genetics ·Vol. 13 ·No. 3 ·1976-06-00 ·Pages 217-22

Zatz M, Penha-Serrano C, Otto PA

Abstract

A family with 24 males affected by an X-linked type of spastic paraplegia is reported. Twelve affected members were personally examined showing the pure form of the disease. Half of the affected males had many descendants, all normal. Linkage studies strongly suggest that this X-linked form of spastic paraplegia and Xg loci are not at a measurable distance on the X chromosome.

MeSH Terms
Blood Group Antigens Color Vision Defects/genetics Female Genetic Linkage Glucosephosphate Dehydrogenase Humans Male Paraplegia/genetics Pedigree Sex Chromosome Aberrations Sex Chromosomes
Chemicals
Blood Group Antigens Glucosephosphate Dehydrogenase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Zatz M
Penha-Serrano C
Otto P A
References (20)
20 references, click to expand
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Article Info
Journal
Journal of medical genetics
Abbr.
J Med Genet
ISSN
0022-2593
DOI
10.1136/jmg.13.3.217
Published
1976-06-00
Pages
217-22
Language
English
Region
England
NLM ID
2985087R
PMCID
PMC1013396
Subset
IM
External Links
PubMed source DOI: 10.1136/jmg.13.3.217 PMC Full Text View journal details
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