Requirement for T cells in the antibody response of mice to calf skin collagen.

Immunology ·Vol. 30 ·No. 1 ·1976-01-00 ·Pages 29-32

Nowack H, Hahn E, Timpl R

Abstract

The antibody response to triple-helical calf skin collagen is apparently regulated by T cells since nude mice (BALB/c strain) responded to this antigen only after transfer of T cells. Syngeneic transfer of B and T cells was required to prepare thymectomized and irradiated normal C57B1/10 recipients for an anti-collagen response. Reconstitution by B cells alone was unsuccessful. The results are compatible with previous evidence on the H-2 linked genetic control of the antibody response to and the non-repetitious nature of helical antigenic determinants in calf collagen.

MeSH Terms

Animals Antibody Formation B-Lymphocytes/immunology Collagen/immunology Immunization, Passive Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude T-Lymphocytes/immunology Thymectomy

Chemicals

Collagen

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Nowack H

Hahn E

Timpl R

References (13)

13 references, click to expand

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Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1976-01-00

Pages

29-32

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1444952

Subset

External Links

PubMed source PMC Full Text View journal details

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Requirement for T cells in the antibody response of mice to calf skin collagen.

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