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PMID: 10823947 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Reduced X-linked nucleotide polymorphism in Drosophila simulans.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 97 ·No. 11 ·2000-05-23 ·Pages 5960-5

Begun DJ, Whitley P

Abstract

Population genetic theory predicts that selectively driven changes of allele frequency for both beneficial and deleterious mutants reduce polymorphism at tightly linked sites. All else being equal, these reductions in polymorphism are expected to be greater when recombination rates are lower. Therefore, the empirical observation of a positive correlation between recombination rates and amounts of DNA polymorphism across the Drosophila melanogaster genome can be explained by two very different types of natural selection. Here, we evaluate alternative models of effects of selection on linked sites by comparison of X-linked and autosomal variation. We present polymorphism data from 40 genes distributed across chromosome arms X and 3R of Drosophila simulans, a sibling species of D. melanogaster. We find significantly less silent polymorphism in D. simulans on the X chromosome than on 3R, but no difference between arms for silent divergence between species. This pattern is incompatible with predictions from theoretical studies on the effect of negative selection on linked sites. We propose that some form of positive selection having greater effects on sex chromosomes than on autosomes is the better explanation for the D. simulans data.

MeSH Terms
Animals Drosophila/genetics Genes, Insect Genetics, Population In Vitro Techniques Male Molecular Sequence Data Polymorphism, Genetic/genetics Selection, Genetic X Chromosome/genetics
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Begun D J
Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA. djbegun@mail.utexas.edu
Whitley P
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.97.11.5960
Email
djbegun@mail.utexas.edu
Published
2000-05-23
Pages
5960-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC18541
Subset
IM
Grants
NIGMS NIH HHS · GM55298 · United States
Databases
GENBANK
AF204277, AF204278, AF204279, AF204280, AF204281, AF204282, AF204283, AF204284, AF204285, AF204286, AF204287, AF204288, AF204289, AF204290, AF256057, AF256058, AF256059, AF256060, AF256061, AF256062, AF256063, AF256064, AF256065, AF256066, AF256067, AF256068, AF256069, AF256070, AF256071, AF256072
External Links
PubMed source DOI: 10.1073/pnas.97.11.5960 PMC Full Text View journal details
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