Specific human B lymphocyte alloantigens linked to HL-A.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 12 ·1975-12-00 ·Pages 5103-6

Mann DL, Abelson L, Henkart P, Harris SD, Amos DB

Abstract

Sera, previously found to react specifically with B lymphoid cultured cells, were tested on isolated T and B peripheral blood lymphocytes in a microcytotoxicity assay. Studies were performed on lymphocytes obtained from several large Amish families. The sera used in these studies were cytotoxic to peripheral blood, B lymphocytes, but not cytotoxic to T lymphocytes. The antigens detected followed the inheritance pattern of HL-A haplotypes. The strong linkage disequilibrium with HL-A antigens suggests that genes controlling the expression of B lymphocyte antigens are linked to genes controlling HL-A alloantigens.

MeSH Terms

B-Lymphocytes/analysis,immunology Binding Sites Binding Sites, Antibody Cells, Cultured Female HLA Antigens/analysis Histocompatibility Antigens/analysis Humans Isoantigens/analysis Male Pedigree Protein Binding

Chemicals

HLA Antigens Histocompatibility Antigens Isoantigens

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Mann D L

Abelson L

Henkart P

Harris S D

Amos D B

References (8)

8 references, click to expand

Interaction of aggregated -globulin with B lymphocytes.
J Exp Med. 1972 Jul 1;136(1):191-6 PMID: 4113510
Mixed lymphocyte culture responses of mice. Genetic analysis of the responses to H-2Dd specificities.
J Exp Med. 1974 Apr 1;139(4):851-61 PMID: 4131511
Three closely linked genetic systems relevant to transplantation.
Proc Natl Acad Sci U S A. 1971 Dec;68(12):3031-5 PMID: 4399834
Detection of antigens specific for B-lymphoid cultured cell lines with human alloantisera.
J Exp Med. 1975 Jul 1;142(1):84-9 PMID: 1080182
Corticosteroids as immunosuppressive drugs: a brief perspective.
Transplant Proc. 1975 Mar;7(1):5-6 PMID: 1118895
The serological recognition of the human MLC determinants using a modified cytotoxicity technique.
Tissue Antigens. 1975 Apr;5(2):73-9 PMID: 48292
Recognition by pregnancy serums of non-HL-A alloantigens selectively expressed on B lymphocytes.
J Exp Med. 1975 Apr 1;141(4):924-9 PMID: 47890
Inheritance of a recombinant HL-A haplotype and genetics of the HL-1 region in man.
Nature. 1974 Apr 5;248(448):517-9 PMID: 4274737

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.72.12.5103

Published

1975-12-00

Pages

5103-6

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC388884

Subset

External Links

PubMed source DOI: 10.1073/pnas.72.12.5103 PMC Full Text View journal details

Analysis Services

Specific human B lymphocyte alloantigens linked to HL-A.

Contact

WeChat Official Account