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PMID: 10819522 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

The role of mammary stroma in modulating the proliferative response to ovarian hormones in the normal mammary gland.

Journal of mammary gland biology and neoplasia ·Vol. 3 ·No. 2 ·1998-04-00 ·Pages 117-31

Woodward TL, Xie JW, Haslam SZ

Abstract

Postnatal mammary gland development is highly dependent on the ovarian steroids, estrogen and progesterone. However, evidence from both in vitro and in vivo studies indicates that steroid-induced development occurs indirectly, requiring stromal cooperation in epithelial proliferation and morphogenesis. Stromal cells appear to influence epithelial cell behavior by secretion of growth factors and/or by altering the composition of the extracellular matrix in which epithelial cells reside. This review will discuss the requirement for stromal tissue in modulating proliferative responses to ovarian hormones during postnatal development and the potential role of the EGF, IGF, HGF and FGF3 growth factor families. Additionally, the roles of extracellular matrix proteins, including fibronectin, collagens and laminin, will be summarized.

MeSH Terms
Animals Breast/cytology,physiology Cell Division Estrogens/physiology Female Growth Substances/physiology Humans Mammary Glands, Animal/cytology,physiology Ovary/physiology Progesterone/physiology Stromal Cells/cytology,physiology
Chemicals
Estrogens Growth Substances Progesterone
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Woodward T L
Department of Physiology, Michigan State University, East Lansing 48824-1101, USA.
Xie J W
Haslam S Z
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1023/a:1018738721656
Published
1998-04-00
Pages
117-31
Language
English
Region
United States
NLM ID
9601804
Subset
IM
Grants
NCI NIH HHS · 5R01CA40104 · United States
External Links
PubMed source DOI: 10.1023/a:1018738721656 View journal details
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