A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides.

Animals Blood Coagulation/drug effects Cells/drug effects,metabolism Complement Activation/drug effects Complement Factor H/metabolism Drug Administration Routes Drug Delivery Systems Haplorhini Humans Mice Mutagenicity Tests Nucleic Acid Hybridization/drug effects Oligonucleotides, Antisense/administration & dosage,blood,immunology,pharmacokinetics,toxicity Organ Specificity/drug effects Protein Binding/drug effects RNA/metabolism Rats Thionucleotides/administration & dosage,blood,immunology,pharmacokinetics,toxicity Tissue Distribution

CFH protein, human Oligonucleotides, Antisense Thionucleotides RNA Complement Factor H