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PMID: 10786633 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF.

Biochimica et biophysica acta ·Vol. 1490 ·No. 1-2 ·2000-01-31 ·Pages 170-4

Neal KC, Pannuti A, Smith ER, Lucchesi JC

Abstract

We have identified a novel human gene product, hMOF, which exhibits significant similarity to the Drosophila dosage compensation regulator, MOF. A recombinant C-terminal portion of hMOF has histone acetyltransferase activity directed toward histones H3, H2A and H4, a specificity characteristic of other MYST family histone acetyltransferases. Based on hMOF's chromodomain, we discuss possible interactions with other proteins.

MeSH Terms

Acetyltransferases/chemistry,genetics Amino Acid Sequence Dosage Compensation, Genetic Drosophila Proteins Histone Acetyltransferases Humans Molecular Sequence Data Nuclear Proteins Saccharomyces cerevisiae Proteins Transfection

Chemicals

Drosophila Proteins Nuclear Proteins Saccharomyces cerevisiae Proteins Acetyltransferases Histone Acetyltransferases KAT7 protein, human KAT8 protein, human mof protein, Drosophila

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Neal K C

Department of Biology, Emory University, Atlanta, GA 30322, USA.

Pannuti A

Smith E R

Lucchesi J C

Article Info

Journal

Biochimica et biophysica acta

Abbr.

Biochim Biophys Acta

ISSN

0006-3002

DOI

10.1016/s0167-4781(99)00211-0

Published

2000-01-31

Pages

170-4

Language

English

Region

Netherlands

NLM ID

0217513

Subset

Grants

NIGMS NIH HHS · GM15691 · United States

NIGMS NIH HHS · GM18038 · United States

Databases

GENBANK

AF100615, AF117065

External Links

PubMed source DOI: 10.1016/s0167-4781(99)00211-0

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A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF.

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