Adapter proteins in lymphocyte antigen-receptor signaling.

Current opinion in immunology ·Vol. 12 ·No. 3 ·2000-06-00 ·Pages 256-66

Myung PS, Boerthe NJ, Koretzky GA

Abstract

Adapter molecules contain discrete modular domains that direct specific intermolecular interactions to orchestrate assembly of signaling complexes. A number of adapter proteins play critical roles in both positive and negative regulation of antigen-receptor signaling, influencing lymphocyte development and function.

MeSH Terms

Lymphocytes/immunology Models, Immunological Proteins/metabolism Receptors, Antigen/metabolism Receptors, Antigen, B-Cell/metabolism Receptors, Antigen, T-Cell/metabolism Signal Transduction

Chemicals

Proteins Receptors, Antigen Receptors, Antigen, B-Cell Receptors, Antigen, T-Cell

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Myung P S

Graduate Program of Immunology, University of Pennsylvania, The Leonard and Madlyn Abramson Family Cancer Research Institute, Philadelphia, PA 19104-6160, USA.

Boerthe N J

Koretzky G A

Article Info

Journal

Current opinion in immunology

Abbr.

Curr Opin Immunol

ISSN

0952-7915

DOI

10.1016/s0952-7915(00)00085-6

Published

2000-06-00

Pages

256-66

Language

English

Region

England

NLM ID

8900118

Subset

External Links

PubMed source DOI: 10.1016/s0952-7915(00)00085-6 View journal details

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