The metalloproteinase inhibitor GI5402 inhibits endotoxin-induced soluble CD27 and CD16 release in healthy humans.

Infection and immunity ·Vol. 68 ·No. 5 ·2000-05-00 ·Pages 3036-9

Dekkers PE, ten Hove T, Lauw FN, Koene HR, Lumley P, van Deventer SJ, van der Poll T

Abstract

Metalloproteinases have been implicated in the cleavage of a number of cell surface immune receptors. Oral administration of the metalloproteinase inhibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circulation after intravenous endotoxin injection in healthy humans.

MeSH Terms

Adult Enzyme Inhibitors/administration & dosage,pharmacology Health Status Humans Lipopolysaccharides/administration & dosage,immunology Male Matrix Metalloproteinase Inhibitors Matrix Metalloproteinases/immunology Receptors, IgG/biosynthesis Solubility Tumor Necrosis Factor Receptor Superfamily, Member 7/biosynthesis

Chemicals

Enzyme Inhibitors Lipopolysaccharides Matrix Metalloproteinase Inhibitors Receptors, IgG Tumor Necrosis Factor Receptor Superfamily, Member 7 Matrix Metalloproteinases

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Dekkers P E

Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. P.E.Dekkers@AMC.UVA.NL

ten Hove T

Lauw F N

Koene H R

Lumley P

van Deventer S J

van der Poll T

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19 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/IAI.68.5.3036-3039.2000

p.e.dekkers@amc.uva.nl

Published

2000-05-00

Pages

3036-9

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC97526

Subset

External Links

PubMed source DOI: 10.1128/IAI.68.5.3036-3039.2000 PMC Full Text View journal details

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The metalloproteinase inhibitor GI5402 inhibits endotoxin-induced soluble CD27 and CD16 release in healthy humans.

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