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题目:: Translocation and coamplification of loci from chromosome arms 8p and 11q in the MDA-MB-175 mammary carcinoma cell line.
作者:: Adélaïde(J),Chaffanet(M),Mozziconacci(M J),Popovici(C),Conte(N),Fernandez(F),Sobol(H),Jacquemier(J),Pébusque(M),Ron(D),Lafage-Pochitaloff(M),Birnbaum(D)
状态:: 发布时间2000-05-11 , 更新时间 2013-11-21
期刊:: Int J Oncol
摘要:: Rearrangement and coamplification of the 8p12 and 11q13 chromosomal regions occurs in a significant proportion of breast cancers. It usually involves a complex hybrid structure in which the FGFR1 and CCND1 genes are amplified. We report here a different type of 8p12-11q13 rearrangement in the MDA-MB-175 mammary carcinoma cell line. This amplification contains the NRG1/HGL (from 8p12-21) and DOC4 (from 11q13) genes, encoding respectively a ligand for ERBB receptors and a stress-induced protein which is a mammalian ortholog of Drosophila Tenm/Odz. It has been shown previously (Wang et al, Oncogene 18: 5718-5721, 1999) that these two genes are rearranged and fused by a translocation event. This type of event was not found in 30 tumors tested that showed coamplification of the 8p12 and 11q13 regions.
语言:: eng
DOI:

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