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PMID: 10694882 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Histone deacetylases: silencers for hire.

Trends in biochemical sciences ·Vol. 25 ·No. 3 ·2000-03-00 ·Pages 121-6

Ng HH, Bird A

Abstract

Over the past few years, the long-standing idea that covalent modification of chromatin can play a role in determining states of gene activity has been confirmed. Eukaryotic genes can be silenced by deacetylation of acetyl-lysine moieties in the N-terminal tails of histones. Recent work links histone deacetylases with an increasing number of repressors, suggesting that deacetylation might be a rather pervasive feature of transcriptional repression systems.

MeSH Terms
Animals Carrier Proteins/metabolism DNA-Binding Proteins/metabolism Gene Silencing Histone Deacetylases/physiology Humans Ikaros Transcription Factor Nuclear Proteins/metabolism Nuclear Receptor Co-Repressor 1 Proto-Oncogene Proteins/metabolism Repressor Proteins/metabolism Saccharomyces cerevisiae Proteins Smad3 Protein Trans-Activators/metabolism Transcription Factors/metabolism Tumor Suppressor Protein p53/metabolism
Chemicals
Carrier Proteins DNA-Binding Proteins IKZF1 protein, human IKZF3 protein, human NCOR1 protein, human Nuclear Proteins Nuclear Receptor Co-Repressor 1 Proto-Oncogene Proteins Repressor Proteins SIN3 protein, S cerevisiae SMAD3 protein, human Saccharomyces cerevisiae Proteins Smad3 Protein Trans-Activators Transcription Factors Tumor Suppressor Protein p53 SKI protein, human Ikaros Transcription Factor MTA2 protein, human Histone Deacetylases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ng H H
Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, Edinburgh, UK EH9 3JR.
Bird A
Article Info
Journal
Trends in biochemical sciences
Abbr.
Trends Biochem Sci
ISSN
0968-0004
DOI
10.1016/s0968-0004(00)01551-6
Published
2000-03-00
Pages
121-6
Language
English
Region
England
NLM ID
7610674
Subset
IM
External Links
PubMed source DOI: 10.1016/s0968-0004(00)01551-6 View journal details
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