Home LiteratureArticle Details
PMID: 1069305 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Heat mutagenesis in bacteriophage T4: the transversion pathway.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 11 ·1976-11-00 ·Pages 4159-63

Bingham PM, Baltz RH, Ripley LS, Drake JW

Abstract

Heat induces transversions (as well as transitions) at G-C base pairs in bacteriophage T4. The target base for transversions is guanine,which is converted to a product which is sometimes replicated and transcribed as a pyrimidine.A model for this process is proposed in which the deoxyguanosine glycosidic bond migrates from N9 to N2: the resulting deoxyneoguanosine may pair with normal guanine to produce G-C leads to C-G transversions.

MeSH Terms
Base Sequence Coliphages Guanine Nucleotides Hot Temperature Hydrogen Bonding Kinetics Mutation
Chemicals
Guanine Nucleotides
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bingham P M
Baltz R H
Ripley L S
Drake J W
References (23)
23 references, click to expand
  1. Transversion mutagenesis in bacteriophage T4.
    Mol Gen Genet. 1975 Nov 3;141(1):23-40 PMID: 765723
  2. Spontaneous mutations accumulating in bacteriophage T4 in the complete absence of DNA replication.
    Proc Natl Acad Sci U S A. 1966 Apr;55(4):738-43 PMID: 5219679
  3. Kinetics and mechanism of the acid-catalyzed hydrolysis of some purine nucleosides.
    J Am Chem Soc. 1970 Mar 25;92(6):1741-9 PMID: 5418456
  4. Properties of r mutants of bacteriophage T4 photodynamically induced in the presence of thiopyronin and psoralen.
    J Virol. 1967 Apr;1(2):260-7 PMID: 5623962
  5. EFFECTS OF HEATING DRY BACTERIA AND SPORES ON THEIR PHENOTYPE AND GENOTYPE.
    Proc Natl Acad Sci U S A. 1960 Jan;46(1):101-5 PMID: 16590581
  6. On the molecular explanation of spontaneous and induced mutations.
    Brookhaven Symp Biol. 1959 Nov;No 12:63-75 PMID: 13824776
  7. NEO-GUANYLIC ACID PRODUCED BY THE ACTION OF ACID ON RIBONUCLEIC ACID.
    Biochim Biophys Acta. 1964 Oct 16;91:332-4 PMID: 14240653
  8. Mutagenesis of bacteriophage T4 by acridines.
    J Mol Biol. 1961 Dec;3:762-8 PMID: 14482221
  9. Studies on depurination of DNA by heat.
    J Mol Biol. 1962 Mar;4:123-41 PMID: 13901601
  10. Reversal of mutant phenotypes by 5-fluorouracil: an approach to nucleotide sequences in messenger-RNA.
    Proc Natl Acad Sci U S A. 1962 Apr 15;48:532-46 PMID: 13877975
  11. A change from nonsense to sense in the genetic code.
    Proc Natl Acad Sci U S A. 1962 Jul 15;48:1114-21 PMID: 13867417
  12. Transitions and transversions induced by depurinating agents.
    Proc Natl Acad Sci U S A. 1961 Apr 15;47:540-5 PMID: 13701660
  13. Heat as an agent producing high frequency of mutations and unstable genes in Escherichia coli.
    Nature. 1958 Aug 30;182(4635):611-3 PMID: 13577928
  14. The formation apurinic acid from the desoxyribonucleic acid of calf thymus.
    J Biol Chem. 1952 Mar;195(1):49-63 PMID: 14938354
  15. Transcription in vitro from a DNA template containing apurinic sites.
    Biochim Biophys Acta. 1974 Mar 27;340(3):237-43 PMID: 4596863
  16. The genetic control of spontaneous and induced mutation rates in bacteriophage T4.
    Genetics. 1973 Apr;73:Suppl 73:45-64 PMID: 4711557
  17. Thymineless mutagenesis in bacteriophage T4.
    Genetics. 1973 Jul;74(3):393-403 PMID: 4270369
  18. Misrepair mutagenesis in bacteriophage T4.
    Genetics. 1974 Sep;78(1):81-9 PMID: 4374410
  19. Rate of depurination of native deoxyribonucleic acid.
    Biochemistry. 1972 Sep 12;11(19):3610-8 PMID: 4626532
  20. The psu1+ amber suppressor gene of bacteriophage T4: identification of its amino acid and transfer RNA.
    J Mol Biol. 1973 Dec 5;81(2):157-71 PMID: 4591185
  21. Heat mutagenesis in bacteriophage T4: the transition pathway.
    Proc Natl Acad Sci U S A. 1976 Apr;73(4):1269-73 PMID: 4797
  22. Characteristics of mutations appearing spontaneously in extracellular particles of bacteriophage T4.
    Genetics. 1967 Mar;55(3):387-98 PMID: 5341474
  23. Genetic code: the 'nonsense' triplets for chain termination and their suppression.
    Nature. 1965 Jun 5;206(988):994-8 PMID: 5320272
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.11.4159
Published
1976-11-00
Pages
4159-63
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC431367
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.11.4159 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2