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PMID: 1069290 Published · ppublish English Journal Article

Simultaneous synthesis of types I and III collagen by fibroblasts in culture.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 11 ·1976-11-00 ·Pages 4037-40

Gay S, Martin GR, Muller PK, Timpl R, Kuhn K

Abstract

Specific antibodies against types I and III collagens and procollagens were used to localize these proteins in cultured human cells. These studies indicate that the same cell makes both proteins. No type III procollagen synthesis was observed in cells from two patients with two patients with the Ehlers-Danlos type IV syndrome.

MeSH Terms
Ascorbic Acid/pharmacology Cell Line Collagen/biosynthesis,immunology Ehlers-Danlos Syndrome/metabolism Fibroblasts/metabolism Humans Procollagen/biosynthesis,immunology Skin
Chemicals
Procollagen Collagen Ascorbic Acid
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Gay S
Martin G R
Muller P K
Timpl R
Kuhn K
References (23)
23 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.11.4037
Published
1976-11-00
Pages
4037-40
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC431318
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.11.4037 PMC Full Text View journal details
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