Tyrosine kinase SYK: essential functions for immunoreceptor signalling.

Immunology today ·Vol. 21 ·No. 3 ·2000-03-00 ·Pages 148-54

Turner M, Schweighoffer E, Colucci F, Di Santo JP, Tybulewicz VL

Abstract

The tyrosine kinase SYK plays critical roles in signalling through immune receptors. Gene-targeting studies have identified the cell types that require SYK for development and function, and the receptors that use SYK as well as their downstream signalling effectors. There is also evidence of a role for SYK in non-immune cells and in the maintenance of vascular integrity.

MeSH Terms

Animals B-Lymphocytes/immunology Blood Platelets/immunology Enzyme Precursors/immunology Humans Intracellular Signaling Peptides and Proteins Killer Cells, Natural/immunology Protein-Tyrosine Kinases/immunology Receptors, Fc/metabolism Receptors, Immunologic/metabolism Signal Transduction Syk Kinase T-Lymphocyte Subsets/immunology ZAP-70 Protein-Tyrosine Kinase

Chemicals

Enzyme Precursors Intracellular Signaling Peptides and Proteins Receptors, Fc Receptors, Immunologic Protein-Tyrosine Kinases SYK protein, human Syk Kinase ZAP-70 Protein-Tyrosine Kinase ZAP70 protein, human

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Turner M

Molecular Immunology Programme, The Babraham Institute, Cambridge, UK CB2 4AT. martin.turner@bbsrc.ac.uk

Schweighoffer E

Colucci F

Di Santo J P

Tybulewicz V L

Article Info

Journal

Immunology today

Abbr.

Immunol Today

ISSN

0167-5699

DOI

10.1016/s0167-5699(99)01574-1

martin.turner@bbsrc.ac.uk

Published

2000-03-00

Pages

148-54

Language

English

Region

England

NLM ID

8008346

Subset

Grants

British Heart Foundation · FS/12/4/29254 · United Kingdom

External Links

PubMed source DOI: 10.1016/s0167-5699(99)01574-1

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Tyrosine kinase SYK: essential functions for immunoreceptor signalling.

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