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PMID: 10684937 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Determination of L1 retrotransposition kinetics in cultured cells.

Nucleic acids research ·Vol. 28 ·No. 6 ·2000-03-15 ·Pages 1418-23

Ostertag EM, Prak ET, DeBerardinis RJ, Moran JV, Kazazian HH

Abstract

L1 retrotransposons are autonomous retroelements that are active in the human and mouse genomes. Previously, we developed a cultured cell assay that uses a neomycin phosphotransferase ( neo ) retrotransposition cassette to determine relative retrotransposition frequencies among various L1 elements. Here, we describe a new retrotransposition assay that uses an enhanced green fluorescent protein (EGFP) retrotransposition cassette to determine retrotransposition kinetics in cultured cells. We show that retrotransposition is not detected in cultured cells during the first 48 h post-transfection, but then proceeds at a continuous high rate for at least 16 days. We also determine the relative retrotransposition rates of two similar human L1 retrotransposons, L1(RP)and L1.3. L1(RP)retrotransposed in the EGFP assay at a rate of approximately 0.5% of transfected cells/day, approximately 3-fold higher than the rate measured for L1.3. We conclude that the new assay detects near real time retrotransposition in a single cell and is sufficiently sensitive to differentiate retrotransposition rates among similar L1 elements. The EGFP assay exhibits improved speed and accuracy compared to the previous assay when used to determine relative retrotransposition frequencies. Furthermore, the EGFP cassette has an expanded range of experimental applications.

MeSH Terms
3' Untranslated Regions/genetics Cinnamates Drug Resistance/genetics False Positive Reactions Genes, Reporter/genetics Globins/genetics Green Fluorescent Proteins HeLa Cells Humans Hygromycin B/analogs & derivatives Introns/genetics Kinetics Luminescent Proteins/genetics,metabolism Microscopy, Fluorescence Mutagenesis, Insertional/genetics,methods Puromycin RNA Splicing/genetics Recombination, Genetic/genetics Retroelements/genetics,physiology Sensitivity and Specificity Time Factors Transfection
Chemicals
3' Untranslated Regions Cinnamates Luminescent Proteins Retroelements Green Fluorescent Proteins Hygromycin B hygromycin A Puromycin Globins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ostertag E M
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Prak E T
DeBerardinis R J
Moran J V
Kazazian H H
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
1362-4962
Published
2000-03-15
Pages
1418-23
Language
English
Region
England
NLM ID
0411011
PMCID
PMC111040
Subset
IM
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