Abstract
L1 retrotransposons are autonomous retroelements that are active in the human and mouse genomes. Previously, we developed a cultured cell assay that uses a neomycin phosphotransferase ( neo ) retrotransposition cassette to determine relative retrotransposition frequencies among various L1 elements. Here, we describe a new retrotransposition assay that uses an enhanced green fluorescent protein (EGFP) retrotransposition cassette to determine retrotransposition kinetics in cultured cells. We show that retrotransposition is not detected in cultured cells during the first 48 h post-transfection, but then proceeds at a continuous high rate for at least 16 days. We also determine the relative retrotransposition rates of two similar human L1 retrotransposons, L1(RP)and L1.3. L1(RP)retrotransposed in the EGFP assay at a rate of approximately 0.5% of transfected cells/day, approximately 3-fold higher than the rate measured for L1.3. We conclude that the new assay detects near real time retrotransposition in a single cell and is sufficiently sensitive to differentiate retrotransposition rates among similar L1 elements. The EGFP assay exhibits improved speed and accuracy compared to the previous assay when used to determine relative retrotransposition frequencies. Furthermore, the EGFP cassette has an expanded range of experimental applications.
MeSH Terms
3' Untranslated Regions/genetics
Cinnamates
Drug Resistance/genetics
False Positive Reactions
Genes, Reporter/genetics
Globins/genetics
Green Fluorescent Proteins
HeLa Cells
Humans
Hygromycin B/analogs & derivatives
Introns/genetics
Kinetics
Luminescent Proteins/genetics,metabolism
Microscopy, Fluorescence
Mutagenesis, Insertional/genetics,methods
Puromycin
RNA Splicing/genetics
Recombination, Genetic/genetics
Retroelements/genetics,physiology
Sensitivity and Specificity
Time Factors
Transfection
Chemicals
3' Untranslated Regions
Cinnamates
Luminescent Proteins
Retroelements
Green Fluorescent Proteins
Hygromycin B
hygromycin A
Puromycin
Globins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ostertag E M
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Prak E T
DeBerardinis R J
Moran J V
Kazazian H H
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