Primary structure of the gamma-carboxyglutamic acid-containing protein from bovine bone.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 10 ·1976-10-00 ·Pages 3374-5

Price PA, Poser JW, Raman N

Abstract

The amino-acid sequence of the gamma-carboxyglutamic acid-containing protein of bovine bone is presented. The sequence of 43 of the 49 residues was determined automatically on the intact protein and on a tryptic peptide. The remainder was determined by conventional procedures on tryptic and chymotrytic peptides. Residue 9 in the sequence has been identified as 4-hydroxyproline. The protein contains three gamma-carboxyglutamic acid residues, which are located at positions 17, 21, and 24. The role of these unusual amino acids in the binding interaction between the protein and hydroxyapatite crystals is discussed.

MeSH Terms

Amino Acid Sequence Animals Bone and Bones/analysis Cattle Glutamates/analysis Proteins/analysis

Chemicals

Glutamates Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Price P A

Poser J W

Raman N

References (14)

14 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.73.10.3374

Published

1976-10-00

Pages

3374-5

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC431116

Subset

External Links

PubMed source DOI: 10.1073/pnas.73.10.3374 PMC Full Text View journal details

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Primary structure of the gamma-carboxyglutamic acid-containing protein from bovine bone.

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