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PMID: 10683368 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Gene silencing as a threat to the success of gene therapy.

The Journal of clinical investigation ·Vol. 105 ·No. 4 ·2000-02-00 ·Pages 409-11

Bestor TH

Abstract

暂无摘要

MeSH Terms
Animals DNA, Viral/genetics Gene Silencing Genetic Therapy/methods Repetitive Sequences, Nucleic Acid Retroviridae/genetics Transcription, Genetic Transgenes
Chemicals
DNA, Viral
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Bestor T H
Department of Genetics, College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, New York 10032, USA. THB12@columbia.edu
References (21)
21 references, click to expand
  1. Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus.
    J Clin Invest. 1999 Nov;104(9):1245-55 PMID: 10545523
  2. A species of small antisense RNA in posttranscriptional gene silencing in plants.
    Science. 1999 Oct 29;286(5441):950-2 PMID: 10542148
  3. Targeted mRNA degradation by double-stranded RNA in vitro.
    Genes Dev. 1999 Dec 15;13(24):3191-7 PMID: 10617568
  4. Specific interference with gene function by double-stranded RNA in early mouse development.
    Nat Cell Biol. 2000 Feb;2(2):70-5 PMID: 10655585
  5. Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissues.
    Proc Natl Acad Sci U S A. 1985 Mar;82(5):1451-5 PMID: 2579397
  6. Activation of endogenous retroviral genomes in Mov strains of mice.
    J Gen Virol. 1987 Nov;68 ( Pt 11):2919-23 PMID: 3681267
  7. The methylation-free status of a housekeeping transgene is lost at high copy number.
    Gene. 1990 Jul 16;91(2):179-84 PMID: 2210379
  8. Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes.
    Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1330-4 PMID: 1847517
  9. Epigenetic effects in eukaryotic gene expression.
    Dev Genet. 1994;15(6):458-62 PMID: 7834904
  10. Creation of genomic methylation patterns.
    Nat Genet. 1996 Apr;12(4):363-7 PMID: 8630488
  11. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells.
    Development. 1996 Oct;122(10):3195-205 PMID: 8898232
  12. Epigenetic phenomena in filamentous fungi: useful paradigms or repeat-induced confusion?
    Trends Genet. 1997 Aug;13(8):296-301 PMID: 9260514
  13. Cytosine methylation and the ecology of intragenomic parasites.
    Trends Genet. 1997 Aug;13(8):335-40 PMID: 9260521
  14. Activation of the lac repressor in the transgenic mouse.
    Genetics. 1997 Sep;147(1):297-304 PMID: 9286689
  15. Transgene repeat arrays interact with distant heterochromatin and cause silencing in cis and trans.
    Genetics. 1997 Nov;147(3):1181-90 PMID: 9383061
  16. Cytosine methylation targetted to pre-determined sequences.
    Nat Genet. 1997 Dec;17(4):376-8 PMID: 9398832
  17. Repeat-induced gene silencing in mammals.
    Nat Genet. 1998 Jan;18(1):56-9 PMID: 9425901
  18. Position effects and epigenetic silencing of plant transgenes.
    Curr Opin Plant Biol. 1998 Apr;1(2):142-8 PMID: 10066569
  19. Sustained gene expression in transplanted skin fibroblasts in rats.
    Gene Ther. 1999 May;6(5):840-4 PMID: 10505109
  20. Epigenetics: regulation through repression.
    Science. 1999 Oct 15;286(5439):481-6 PMID: 10521337
  21. Improved expression in hematopoietic and lymphoid cells in mice after transplantation of bone marrow transduced with a modified retroviral vector.
    Blood. 1999 Nov 15;94(10):3349-57 PMID: 10552944
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
Published
2000-02-00
Pages
409-11
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC289175
Subset
IM
Grants
NIGMS NIH HHS · GM59377 · United States
NICHD NIH HHS · HD37687 · United States
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