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PMID: 10678997 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effects of iron on extracellular and intracellular growth of Penicillium marneffei.

Infection and immunity ·Vol. 68 ·No. 3 ·2000-03-00 ·Pages 1724-6

Taramelli D, Brambilla S, Sala G, Bruccoleri A, Tognazioli C, Riviera-Uzielli L, Boelaert JR

Abstract

Killing of intracellular Penicillium marneffei conidia is demonstrated in gamma interferon-lipopolysaccharide-activated human THP1 and mouse J774 cells. Iron overload significantly reduces the antifungal activity of macrophages. Likewise, exogenous iron enhances and iron chelators inhibit the extracellular growth of P. marneffei. These results suggest that iron availability critically affects immunity to and the pathogenicity of P. marneffei.

MeSH Terms
Animals Deferoxamine/pharmacology Humans Interferon-gamma/pharmacology Iron/pharmacology Iron Overload/microbiology Lipopolysaccharides/pharmacology Mice Nitric Oxide/physiology Penicillium/drug effects,growth & development
Chemicals
Lipopolysaccharides Nitric Oxide Interferon-gamma Iron Deferoxamine
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Taramelli D
Istituto di Microbiologia, Università di Milano, Milan, Italy. Donatella.Taramelli@unimi.it
Brambilla S
Sala G
Bruccoleri A
Tognazioli C
Riviera-Uzielli L
Boelaert J R
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16 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.68.3.1724-1726.2000
Email
donatella.taramelli@unimi.it
Published
2000-03-00
Pages
1724-6
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC97338
Subset
IM
External Links
PubMed source DOI: 10.1128/IAI.68.3.1724-1726.2000 PMC Full Text View journal details
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