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PMID: 1067621 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Morphinomimetic activity of synthetic fragments of beta-lipotropin and analogs.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 9 ·1976-09-00 ·Pages 3308-10

Ling N, Guillemin R

Abstract

In the myenteric plexus-longitudinal muscle bioassay, beta-endorphin, i.e., beta-lipotropin (beta-LPH)-[61-91], has a potency of 450 with confidence limits of 281-966 when Met5-enkephalin is used as a reference standard with a potency of 100. The primary amide and the ethylamide of Met5-enkephalin have potencies statistically overlapping with that of beta-endorphin. The primary amide of alpha-endorphin has twice the potency of the free acid form of alpha-endorphin. An intact NH2-terminal tyrosine is not necessary for full intrinsic activity. The shortest fragment of beta-LPH with morphinomimetic activity is beta-LPH-[61-64].

MeSH Terms
Amino Acid Sequence Animals Biological Assay Guinea Pigs Oligopeptides/pharmacology Peptide Fragments/pharmacology Structure-Activity Relationship beta-Lipotropin/pharmacology
Chemicals
Oligopeptides Peptide Fragments beta-Lipotropin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ling N
Guillemin R
References (16)
16 references, click to expand
  1. The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips.
    J Physiol. 1968 Jan;194(1):13-33 PMID: 4295753
  2. Interactions of narcotic antagonists with receptor sites.
    Adv Biochem Psychopharmacol. 1973;8(0):471-81 PMID: 4212101
  3. ACTH-like peptides and opiate receptors in the rat brain: structure-activity studies.
    Eur J Pharmacol. 1975 Sep-Oct;33(2):395-9 PMID: 241656
  4. Effect of peptides and amino acids on dihydromorphine binding to the opiate receptor.
    J Pharm Pharmacol. 1975 Jun;27(6):450-2 PMID: 237099
  5. [Endorphins, hypothalamic and neurohypophysial peptides with morphinomimetic activity: isolation and molecular structure of alpha-endorphin].
    C R Acad Sci Hebd Seances Acad Sci D. 1976 Feb 23;282(8):783-5 PMID: 817843
  6. Analogs of luteinizing hormone releasing factor (LRF). Synthesis and biological activity of ((Nalpha-Me)Leu-7)LRF and (D-Ala-6,(Nalpha-Me)Leu-7)LRF.
    Biochem Biophys Res Commun. 1975 Apr 7;63(3):801-6 PMID: 1093545
  7. Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor.
    Proc Natl Acad Sci U S A. 1976 Jul;73(7):2515-9 PMID: 1065904
  8. Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands.
    Proc Natl Acad Sci U S A. 1976 Apr;73(4):1145-8 PMID: 1063395
  9. beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins.
    Proc Natl Acad Sci U S A. 1976 Jun;73(6):2156-9 PMID: 1064883
  10. Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.
    Proc Natl Acad Sci U S A. 1976 Jun;73(6):1821-3 PMID: 1064855
  11. Analogues of luteinizing hormone releasing factor modified at positions 2, 6, and 10.
    J Med Chem. 1976 Jul;19(7):937-41 PMID: 781247
  12. Structural and conformational relationships between the enkephalins and the opiates.
    Nature. 1976 Apr 29;260(5554):795-7 PMID: 1264259
  13. C fragment of lipotropin has a high affinity for brain opiate receptors.
    Nature. 1976 Apr 29;260(5554):793-5 PMID: 1264258
  14. Evidence for analgesic activity of enkephalin in the mouse.
    Nature. 1976 Jun 3;261(5559):423-5 PMID: 934276
  15. A synthetic peptide with morphine-like pharmacologic action.
    Life Sci. 1975 Dec 1;17(11):1643-54 PMID: 1207378
  16. Identification of two related pentapeptides from the brain with potent opiate agonist activity.
    Nature. 1975 Dec 18;258(5536):577-80 PMID: 1207728
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.9.3308
Published
1976-09-00
Pages
3308-10
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC431021
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.9.3308 PMC Full Text View journal details
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