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PMID: 1067604 Published · ppublish English Journal Article

Correlation of degradative rates of proteins with a parameter calculated from amino acid composition and subunit size.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 9 ·1976-09-00 ·Pages 3093-7

Momany FA, Aguanno JJ, Larrabee AR

Abstract

A parameter is developed which relates the amino acid composition and subunit size of a protein to the degradative rate in vivo. This parameter was calculated for 11 rat liver proteins and a plot versus the half-lives of these proteins is linear and has a coefficient of correlation of -0.96. Evidence is presented which suggests that the density of excess acidic amino acids on the surface of the protein is the most important factor in determining differential turnover.

MeSH Terms
Amino Acids/analysis Animals Cattle Enzymes/metabolism Half-Life Liver/metabolism Mice Models, Biological Molecular Weight Muscles/metabolism Protein Conformation Proteins/metabolism Rabbits Rats Structure-Activity Relationship Surface Properties Swine
Chemicals
Amino Acids Enzymes Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Momany F A
Aguanno J J
Larrabee A R
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50 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.9.3093
Published
1976-09-00
Pages
3093-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC430940
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.9.3093 PMC Full Text View journal details
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