A possible conformation for double-stranded polynucleotides.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 9 ·1976-09-00 ·Pages 2959-63

Rodley GA, Scobie RS, Bates RH, Lewitt RM

Abstract

A model is presented for double-stranded polynucleotides which involves side-by-side meshing of the two strands rather than double helical intertwining. The sugar-phosphate backbone has a twisted strip-like character, yet base-pairing of the Watson-Crick type is still possible. Structural features of the basic model are described and coordinates are presented for a representative example. The structure has, on the whole, reasonable sterochemical contacts, and can be shown to produce a fiber diffraction pattern with x-rays not unlike that of the B form of DNA.

MeSH Terms

DNA Models, Molecular Models, Structural Nucleic Acid Conformation Poly C Poly G RNA Thermodynamics X-Ray Diffraction

Chemicals

Poly G Poly C RNA DNA

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Rodley G A

Scobie R S

Bates R H

Lewitt R M

References (8)

8 references, click to expand

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Ethidium bromide as a cooperative effector of a DNA structure.
Proc Natl Acad Sci U S A. 1972 Dec;69(12):3805-9 PMID: 4509343
Structural details of double-helix observed for DNAs containing alternating purine and pyrimidine sequences.
J Mol Biol. 1974 Sep 15;88(2):523-33 PMID: 4453006
Conformational studies on pyrimidine 5'-monophosphates and 3',5'-diphosphates. Effect of the phosphate groups on the backbone conformation of polynucleotides.
Biopolymers. 1973;12(10):2261-77 PMID: 4757323
Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC).
J Mol Biol. 1972 Jun 28;67(3):375-96 PMID: 5045303
Kinky helix.
Nature. 1975 Jun 12;255(5509):530-3 PMID: 1095931
Polymorphism of a synthetic DNA in solution.
Nature. 1976 Mar 25;260(5549):365-6 PMID: 1256581
An uncommon nucleotide conformation shown by molecular structure of deoxyuridine-5'-phosphate and nucleic acid stereochemistry.
Nature. 1975 Dec 11;258(5535):542-4 PMID: 1196389

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.73.9.2959

Published

1976-09-00

Pages

2959-63

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC430891

Subset

External Links

PubMed source DOI: 10.1073/pnas.73.9.2959 PMC Full Text View journal details

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A possible conformation for double-stranded polynucleotides.

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