| GeneLibs

题目:: Coordinate recruitment of E-cadherin and ALCAM to cell-cell contacts by alpha-catenin.
作者:: Tomita(K),van Bokhoven(A),Jansen(C F),Bussemakers(M J),Schalken(J A)
状态:: 发布时间2000-03-09 , 更新时间 2005-11-17
期刊:: Biochem Biophys Res Commun
摘要:: Here we report on the role of alpha-catenin in the cellular localization of activated leukocyte cell adhesion molecule, ALCAM, and cadherin-mediated cell adhesion in human prostate cancer cells. Cell lines that have a functional E-cadherin-mediated cell adhesion (DU-145 and LNCaP) show ALCAM staining at cell-cell contacts. In contrast, in cell lines that lack alpha-catenin expression (ALVA-31, PC-3, and PPC-1), E-cadherin-mediated adhesion is disturbed and ALCAM staining is cytoplasmic. A role of alpha-catenin in the recruitment of E-cadherin and ALCAM to cell-cell contacts was established by transfection of an alpha-N-catenin construct into cell lines ALVA-31 and PC-3. This resulted not only in the correct assembly of E-cadherin/alpha-catenin complexes at the cell membrane but also in localization of ALCAM to cell-cell contacts, indicating that indeed alpha-catenin affects ALCAM localization.
语言:: eng
DOI:

文献库文献相关信息