Formation of endogenous "antiinflammatory" lipid mediators by transcellular biosynthesis. Lipoxins and aspirin-triggered lipoxins inhibit neutrophil recruitment and vascular permeability.

Animals Anti-Inflammatory Agents, Non-Steroidal/pharmacology Arachidonic Acids/blood,pharmacology Aspirin/pharmacology Biopsy, Needle Capillary Permeability/drug effects Depression, Chemical Disease Models, Animal Ear Diseases/chemically induced,physiopathology Ear, External/pathology Eicosapentaenoic Acid/analogs & derivatives,blood,pharmacology Inflammation/chemically induced,physiopathology Inflammation Mediators/metabolism Lipids/biosynthesis Mice Mice, Inbred BALB C Mice, Knockout Neutrophil Infiltration/drug effects Peritonitis/chemically induced,physiopathology

Anti-Inflammatory Agents, Non-Steroidal Arachidonic Acids Inflammation Mediators Lipids Eicosapentaenoic Acid Aspirin