Abstract
Differentiation of the embryonic termini in Drosophila depends on signaling by the Tor RTK, which induces terminal gene expression by inactivating at the embryonic poles a uniformly distributed repressor activity that involves the Gro corepressor. Here, we identify a new gene, cic, that acts as a repressor of terminal genes regulated by the Tor pathway. cic also mediates repression along the dorsoventral axis, a process that requires the Dorsal morphogen and Gro, and which is also inhibited by Tor signaling at the termini. cic encodes an HMG-box transcription factor that interacts with Gro in vitro. We present evidence that Tor signaling regulates terminal patterning by inactivating Cic at the embryo poles. cic has been evolutionarily conserved, suggesting that Cic-like proteins may act as repressors regulated by RTK signaling in other organisms.
MeSH Terms
Amino Acid Sequence
Animals
Body Patterning/genetics,physiology
Conserved Sequence
Drosophila Proteins
Drosophila melanogaster/embryology,genetics,growth & development
Evolution, Molecular
Female
HMGB Proteins
High Mobility Group Proteins/genetics,metabolism,physiology
Humans
Molecular Sequence Data
Mutation/genetics
Protein Processing, Post-Translational
Receptor Protein-Tyrosine Kinases/physiology
Repressor Proteins
Signal Transduction/genetics,physiology
Suppression, Genetic
Transcription Factors/genetics,isolation & purification,metabolism,physiology
Chemicals
CIC protein, human
Drosophila Proteins
HMGB Proteins
High Mobility Group Proteins
Repressor Proteins
Transcription Factors
cic protein, Drosophila
Receptor Protein-Tyrosine Kinases
tor protein, Drosophila
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Jiménez G
Institut de Biologia Molecular de Barcelona (CSIC), 08034 Barcelona, Spain.
Guichet A
Ephrussi A
Casanova J
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