Home LiteratureArticle Details
PMID: 10642590 Published · ppublish English Comment Journal Article

Congenital disorders of glycosylation caused by defects in mannose addition during N-linked oligosaccharide assembly.

The Journal of clinical investigation ·Vol. 105 ·No. 2 ·2000-01-00 ·Pages 131-2

Orlean P

Abstract

暂无摘要

MeSH Terms
Carbohydrate Metabolism, Inborn Errors/enzymology,genetics Carbohydrate Sequence Fungal Proteins/genetics Glycosylation Humans Mannose/metabolism Mannosyltransferases/genetics,metabolism Membrane Proteins/genetics Molecular Sequence Data Oligosaccharides/biosynthesis Protein Processing, Post-Translational Saccharomyces cerevisiae Proteins
Chemicals
Fungal Proteins Membrane Proteins Oligosaccharides Saccharomyces cerevisiae Proteins ALG3 protein, S cerevisiae Mannosyltransferases dolichyl-phosphate beta-D-mannosyltransferase Mannose
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Orlean P
Department of Biochemistry, University of Illinois-Urbana-Champaign, 309 Roger Adams Laboratory, 600 South Mathews Avenue, Urbana, Illinois 61801, USA. p-orlean@uiuc.edu
References (19)
19 references, click to expand
  1. Molecular basis of carbohydrate-deficient glycoprotein syndromes type I with normal phosphomannomutase activity.
    Biochim Biophys Acta. 1999 Oct 8;1455(2-3):167-78 PMID: 10571010
  2. Carbohydrate deficient glycoprotein syndrome type IV: deficiency of dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase.
    EMBO J. 1999 Dec 1;18(23):6816-22 PMID: 10581255
  3. A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic.
    Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6982-7 PMID: 10359825
  4. Dolichol phosphate mannose synthase (DPM1) mutations define congenital disorder of glycosylation Ie (CDG-Ie)
    J Clin Invest. 2000 Jan;105(2):191-8 PMID: 10642597
  5. Deficiency of dolichol-phosphate-mannose synthase-1 causes congenital disorder of glycosylation type Ie.
    J Clin Invest. 2000 Jan;105(2):233-9 PMID: 10642602
  6. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3.
    EMBO J. 2000 Jun 1;19(11):2475-82 PMID: 10835346
  7. Yeast mutants deficient in protein glycosylation.
    Proc Natl Acad Sci U S A. 1983 Dec;80(24):7466-70 PMID: 6369318
  8. Assembly of asparagine-linked oligosaccharides.
    Annu Rev Biochem. 1985;54:631-64 PMID: 3896128
  9. Cloning and sequencing of the yeast gene for dolichol phosphate mannose synthase, an essential protein.
    J Biol Chem. 1988 Nov 25;263(33):17499-507 PMID: 3053713
  10. Functional analysis of T-cell mutants defective in the biosynthesis of glycosylphosphatidylinositol anchor. Relative importance of glycosylphosphatidylinositol anchor versus N-linked glycosylation in T-cell activation.
    J Biol Chem. 1991 Dec 5;266(34):23175-84 PMID: 1835975
  11. Biological roles of oligosaccharides: all of the theories are correct.
    Glycobiology. 1993 Apr;3(2):97-130 PMID: 8490246
  12. The carbohydrate-deficient glycoprotein syndromes: pre-Golgi and Golgi disorders?
    Glycobiology. 1993 Oct;3(5):423-8 PMID: 8286854
  13. GPI-anchor biosynthesis.
    Trends Biochem Sci. 1995 Sep;20(9):367-71 PMID: 7482705
  14. Protein C-mannosylation is enzyme-catalysed and uses dolichyl-phosphate-mannose as a precursor.
    Mol Biol Cell. 1998 Feb;9(2):291-300 PMID: 9450955
  15. DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate.
    EMBO J. 1998 Sep 1;17(17):4920-9 PMID: 9724629
  16. Carbohydrate-deficient glycoprotein syndrome type V: deficiency of dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase.
    Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13200-5 PMID: 9789065
  17. The dolichol pathway of N-linked glycosylation.
    Biochim Biophys Acta. 1999 Jan 6;1426(2):239-57 PMID: 9878760
  18. The oligosaccharyltransferase complex from yeast.
    Biochim Biophys Acta. 1999 Jan 6;1426(2):259-73 PMID: 9878773
  19. Protein O-mannosylation.
    Biochim Biophys Acta. 1999 Jan 6;1426(2):297-307 PMID: 9878797
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI9157
Email
p-orlean@uiuc.edu
Published
2000-01-00
Pages
131-2
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC377435
Subset
IM
Corrections
CommentOn
PMID: 10642597
CommentOn
PMID: 10642602
External Links
PubMed source DOI: 10.1172/JCI9157 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2