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PMID: 10631629 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The hereditary spastic paraplegias.

Journal of neurology ·Vol. 246 ·No. 11 ·1999-11-00 ·Pages 995-1003

Reid E

Abstract

The hereditary spastic paraplegias are a complex group of neurodegenerative conditions which are characterised by slowly progressive lower limb spasticity. This article describes the main clinical features of pure and complicated hereditary spastic paraplegias and summarises recent advances in our understanding of the molecular genetics of these conditions.

MeSH Terms
Diagnosis, Differential Genes, Dominant Genes, Recessive Genetic Counseling Genetic Linkage Humans Molecular Biology Paraplegia/diagnosis,genetics,physiopathology,therapy X Chromosome/genetics
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Reid E
Department of Medical Genetics, Cambridge Institute for Medical Research, Addenbrooke's Hospital, UK. ereid@hgmp.mrc.ac.uk
Article Info
Journal
Journal of neurology
Abbr.
J Neurol
ISSN
0340-5354
DOI
10.1007/s004150050503
Email
ereid@hgmp.mrc.ac.uk
Published
1999-11-00
Pages
995-1003
Language
English
Region
Germany
NLM ID
0423161
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1007/s004150050503 View journal details
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