Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication.

Journal of virology ·Vol. 74 ·No. 2 ·2000-01-00 ·Pages 1014-7

Laskus T, Radkowski M, Wang LF, Nowicki M, Rakela J

Abstract

We have found differences among the populations of hepatitis C virus sequences in serum, peripheral blood mononuclear cells (PBMCs), and various tissues in patients with chronic hepatitis C. These results are compatible with the existence of independent viral compartments in the infected host. Our results also suggest that PBMCs, and probably various tissues, can selectively adsorb viral subpopulations differing in the E2 region.

MeSH Terms

5' Untranslated Regions Adsorption Base Sequence Hepacivirus/classification,genetics,physiology Hepatitis C, Chronic/blood,pathology,virology Humans Leukocytes, Mononuclear/virology Liver Failure/pathology,virology Molecular Sequence Data Sequence Homology, Nucleic Acid Tissue Distribution Viral Envelope Proteins/genetics Virion Virus Replication

Chemicals

5' Untranslated Regions Viral Envelope Proteins glycoprotein E2, Hepatitis C virus

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Laskus T

Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA. laskus.tomasz@mayo.edu

Radkowski M

Wang L F

Nowicki M

Rakela J

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13 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/jvi.74.2.1014-1017.2000

laskus.tomasz@mayo.edu

Published

2000-01-00

Pages

1014-7

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC111624

Subset

External Links

PubMed source DOI: 10.1128/jvi.74.2.1014-1017.2000 PMC Full Text View journal details

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Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication.

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