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PMID: 10615891 Published · ppublish English Letter Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Hypocretin (orexin) deficiency in human narcolepsy.

Lancet (London, England) ·Vol. 355 ·No. 9197 ·2000-01-01 ·Pages 39-40

Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E

Abstract

Alterations in the hypocretin receptor 2 and preprohypocretin genes produce narcolepsy in animal models. Hypocretin was undetectable in seven out of nine people with narcolepsy, indicating abnormal hypocretin transmission.

MeSH Terms

Adult Aged Animals Carrier Proteins Dogs Female Humans Intracellular Signaling Peptides and Proteins Male Mice Mice, Knockout Middle Aged Narcolepsy/cerebrospinal fluid,genetics,metabolism Neuropeptides Neurotransmitter Agents/cerebrospinal fluid,deficiency,genetics Orexins

Chemicals

Carrier Proteins Intracellular Signaling Peptides and Proteins Neuropeptides Neurotransmitter Agents Orexins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Nishino S

Ripley B

Overeem S

Lammers G J

Mignot E

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/S0140-6736(99)05582-8

Published

2000-01-01

Pages

39-40

Language

English

Region

England

NLM ID

2985213R

Subset

Grants

NHLBI NIH HHS · HL59601 · United States

NINDS NIH HHS · NS237724 · United States

NINDS NIH HHS · NS33797 · United States

Corrections

CommentIn

PMID: 10615881

CommentIn

PMID: 10711955

CommentIn

PMID: 10770327

External Links

PubMed source DOI: 10.1016/S0140-6736(99)05582-8 View journal details

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Hypocretin (orexin) deficiency in human narcolepsy.

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