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PMID: 1061089 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Plasmid interactions in Staphylococcus aureus: nonadditivity of compatible plasmid DNA pools.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 12 ·1975-12-00 ·Pages 5031-5

Ruby C, Novick RP

Abstract

Six different Staphylococcus aureus plasmids have been examined for compatibility relationships and their intracellular DNA pools have been measured singly and in various combinations. All six were mutually compatible, but contrary to expectation, their intracellular DNA pools were not additive; instead, there appeared to be a maximum level of extrachromosomal DNA that could be supported by the cell, and the plasmids studied approached this level individually as well as in varous combinations. One exception was encountered: a plasmid encoding kanamycin/neomycin resistance was present in a small but constant number of copies regardless of the presence of other plasmids.

MeSH Terms
DNA, Bacterial/metabolism DNA, Circular/metabolism Drug Resistance, Microbial Extrachromosomal Inheritance Kanamycin/pharmacology Phenotype Plasmids/drug effects Staphylococcus aureus/drug effects,metabolism Transduction, Genetic
Chemicals
DNA, Bacterial DNA, Circular Kanamycin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ruby C
Novick R P
References (20)
20 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.72.12.5031
Published
1975-12-00
Pages
5031-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC388869
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.72.12.5031 PMC Full Text View journal details
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