X-ray fiber diffraction evidence for neighbor exclusion binding of a platinum metallointercalation reagent to DNA.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 12 ·1975-12-00 ·Pages 4825-9

Bond PJ, Langridge R, Jennette KW, Lippard SJ

Abstract

Good quality x-ray diffraction patterns have been obtained of polycrystalline fibers containing 2-hydroxyethanethiolato(2,2'2"-terpyridine)platinum(II) bound to calf thymus DNA by intercalation. The photographs strongly support the neighbor exclusion binding model in which electron-dense platinum atoms are regularly distributed at 10.2 A intervals, every other interbase pair site.

MeSH Terms

Animals Binding Sites Cattle DNA Mercaptoethanol/analogs & derivatives Models, Molecular Molecular Conformation Nucleic Acid Conformation Organometallic Compounds Platinum Pyridines Thymus Gland X-Ray Diffraction

Chemicals

Organometallic Compounds Pyridines Platinum Mercaptoethanol DNA

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Bond P J

Langridge R

Jennette K W

Lippard S J

References (19)

19 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.72.12.4825

Published

1975-12-00

Pages

4825-9

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC388824

Subset

External Links

PubMed source DOI: 10.1073/pnas.72.12.4825 PMC Full Text View journal details

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X-ray fiber diffraction evidence for neighbor exclusion binding of a platinum metallointercalation reagent to DNA.

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