Macrophage activation during experimental murine brucellosis: a basis for chronic infection.

Infection and immunity ·Vol. 23 ·No. 2 ·1979-02-00 ·Pages 197-205

Cheers C, Pagram F

Abstract

Evidence is presented that the chronicity of infection in CBA mice after injection of Brucella abortus 19 is related to a number of factors: (i) the relative resistance of B. abortus to macrophage killing, which allowed some bacteria to survive the peak of macrophage activity occurring at 14 days; (ii) the decline in macrophage activity thereafter (this decline was related in part to the presence of fewer bacteria to stimulate the bactericidal activity and also to specific, active suppressor mechanisms not identified in this study); and (iii) the insensitivity of the persistent Brucella organisms to activated macrophages. This was not due to a selection of genetically resistant bacteria, but possibly to their inaccessibility, either within "incompetent" macrophages or outside macrophages altogether.

MeSH Terms

Animals Brucella abortus/growth & development Brucellosis/immunology,microbiology Chronic Disease Female Listeria monocytogenes Listeriosis/immunology Liver/microbiology Macrophages/immunology Male Mice Mice, Inbred CBA Spleen/microbiology

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Cheers C

Pagram F

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26 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.23.2.197-205.1979

Published

1979-02-00

Pages

197-205

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC414148

Subset

External Links

PubMed source DOI: 10.1128/iai.23.2.197-205.1979 PMC Full Text View journal details

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Macrophage activation during experimental murine brucellosis: a basis for chronic infection.

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