Cell proliferation and apoptosis.

Current opinion in cell biology ·Vol. 11 ·No. 6 ·1999-12-00 ·Pages 745-52

Guo M, Hay BA

Abstract

Cell proliferation and cell death are essential yet opposing cellular processes. Crosstalk between these processes promotes a balance between proliferation and death, and it limits the growth and survival of cells with oncogenic mutations. New insights into the mechanisms by which strong signals to proliferate and activation of cyclin-dependent kinases promote apoptosis have recently been published, and a novel cell cycle regulated caspase inhibitor, Survivin, has been described.

MeSH Terms

Animals Apoptosis Carrier Proteins Cell Cycle/physiology Cell Cycle Proteins Cell Division Cyclin-Dependent Kinases/antagonists & inhibitors,physiology DNA-Binding Proteins E2F Transcription Factors Growth Substances/physiology Inhibitor of Apoptosis Proteins Microtubule-Associated Proteins Neoplasm Proteins Oncogenes/physiology Proteins/metabolism,physiology Retinoblastoma Protein/physiology Retinoblastoma-Binding Protein 1 Signal Transduction Survivin Transcription Factors/physiology

Chemicals

BIRC5 protein, human Carrier Proteins Cell Cycle Proteins DNA-Binding Proteins E2F Transcription Factors Growth Substances Inhibitor of Apoptosis Proteins Microtubule-Associated Proteins Neoplasm Proteins Proteins Retinoblastoma Protein Retinoblastoma-Binding Protein 1 Survivin Transcription Factors Cyclin-Dependent Kinases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Guo M

Department of Neurology, University of California in Los Angeles (UCLA) Medical Center, C-128 RNRC, Los Angeles, CA 90095, USA. mingfly@itsa.ucsf.edu.

Hay B A

Article Info

Journal

Current opinion in cell biology

Abbr.

Curr Opin Cell Biol

ISSN

0955-0674

DOI

10.1016/s0955-0674(99)00046-0

mingfly@itsa.ucsf.edu

Published

1999-12-00

Pages

745-52

Language

English

Region

England

NLM ID

8913428

Subset

Corrections

CommentIn

PMID: 10681127

External Links

PubMed source DOI: 10.1016/s0955-0674(99)00046-0 View journal details

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Cell proliferation and apoptosis.

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