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PMID: 10595871 Published · ppublish English Journal Article Review

Signaling of neuronal cell death by the p75NTR neurotrophin receptor.

Molecular neurobiology ·Vol. 20 ·No. 1 ·1999-08-00 ·Pages 29-44

Coulson EJ, Reid K, Bartlett PF

Abstract

The neurotrophin receptor (p75NTR) is best known for mediating tropic support by participating in the formation of high-affinity nerve growth factor (NGF) receptor complexes with trkA, however, p75NTR more recently has been shown to act as a bona fide death-signaling receptor, which can signal independently of trkA. This article discusses the evidence for an active role of p75NTR in neuronal cell death and the mechanisms controlling this process, including roles for Bcl-2 family members, the c-jun stress kinase JNK, the transcription factor nuclear factor kappa B (NFkappaB), and caspases.

MeSH Terms
Animals Apoptosis Caspases/metabolism Neurons/cytology,physiology Receptor, Nerve Growth Factor/physiology Signal Transduction/physiology Stress, Physiological
Chemicals
Receptor, Nerve Growth Factor Caspases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Coulson E J
Development and Neurobiology Group, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Parkville, Australia.
Reid K
Bartlett P F
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Article Info
Journal
Molecular neurobiology
Abbr.
Mol Neurobiol
ISSN
0893-7648
DOI
10.1007/BF02741363
Published
1999-08-00
Pages
29-44
Language
English
Region
United States
NLM ID
8900963
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02741363 View journal details
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