Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis.

Science (New York, N.Y.) ·Vol. 190 ·No. 4217 ·1975-11-28 ·Pages 893-4

Leder A, Orkin S, Leder P

Abstract

Erythroid differentiation can be readily induced by butyric acid in cultured erythroleukemic cells in the presence of inhibitors of DNA synthesis and in the absence of cell division. This result appears to rule out more complex models for globin gene expression which require gene replication or cell division (or both).

MeSH Terms

Butyrates/pharmacology Cell Differentiation/drug effects Cell Line Cytarabine/pharmacology DNA Replication/drug effects DNA, Neoplasm/biosynthesis Hemoglobins/biosynthesis Hydroxyurea/pharmacology Leukemia, Erythroblastic, Acute

Chemicals

Butyrates DNA, Neoplasm Hemoglobins Cytarabine Hydroxyurea

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Leder A

Orkin S

Leder P

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.1059262

Published

1975-11-28

Pages

893-4

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.1059262 View journal details

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Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis.

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