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PMID: 1059091 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

On primary structure and biosynthesis of histidine-rich polypeptide from malarial parasite Plasmodium lophurae.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 8 ·1975-08-00 ·Pages 3057-9

Kilejian A, Liao TH, Trager W

Abstract

Experiments on the primary structure of a histidine-rich polypeptide isolated from the malarial parasite Plasmodium lophurae indicate that the smaller quantities of amino acids other than histidine form an integral part of the polypeptide and do not arise from a protein contaminating a histidine homopolymer. In culture, the parasites incorporate over 50% of exogenously supplied histidine into the histidine-rich polypeptide and this incorporation is inhibited by puromycin.

MeSH Terms
Amino Acid Sequence Amino Acids/analysis Animals Histidine/analysis,metabolism Peptide Biosynthesis Peptides/analysis Plasmodium/metabolism
Chemicals
Amino Acids Peptides Histidine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kilejian A
Liao T H
Trager W
References (9)
9 references, click to expand
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    J Biol Chem. 1968 Dec 10;243(23):6281-3 PMID: 5723468
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    Exp Parasitol. 1959 Jun;8(3):265-73 PMID: 13663908
  6. Cyanophycin Granules from the Blue-Green Alga Anabaena cylindrica: A Reserve Material Consisting of Copolymers of Aspartic Acid and Arginine.
    Proc Natl Acad Sci U S A. 1971 Feb;68(2):265-7 PMID: 16591901
  7. The biosynthesis of the cross-linking peptides in the cell wall peptidoglycan of Staphylococcus aureus.
    J Biol Chem. 1972 Oct 10;247(19):6306-11 PMID: 4568613
  8. Malaria parasites (Plasmodium lophurae) developing extracellularly in vitro: incorporation of labeled precursors.
    J Protozool. 1971 Aug;18(3):392-9 PMID: 5132315
  9. High resolution acrylamide gel electrophoresis of histones.
    Arch Biochem Biophys. 1969 Mar;130(1):337-46 PMID: 5778650
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.72.8.3057
Published
1975-08-00
Pages
3057-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC432918
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.72.8.3057 PMC Full Text View journal details
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