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PMID: 10590149 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Measles virus induces functional TRAIL production by human dendritic cells.

Journal of virology ·Vol. 74 ·No. 1 ·2000-01-00 ·Pages 556-9

Vidalain PO, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C, Servet-Delprat C

Abstract

Measles virus infection induces a profound immunosuppression that can lead to serious secondary infections. Here we demonstrate that measles virus induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA and protein expression in human monocyte-derived dendritic cells. Moreover, measles virus-infected dendritic cells are shown to be cytotoxic via the TRAIL pathway.

MeSH Terms
Apoptosis Regulatory Proteins Cytotoxicity, Immunologic Dendritic Cells/immunology,metabolism,virology Humans In Vitro Techniques Measles virus/physiology Membrane Glycoproteins/genetics RNA, Messenger/biosynthesis,genetics TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor-alpha/genetics
Chemicals
Apoptosis Regulatory Proteins Membrane Glycoproteins RNA, Messenger TNF-Related Apoptosis-Inducing Ligand TNFSF10 protein, human Tumor Necrosis Factor-alpha
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Vidalain P O
Laboratoire d'Immunobiologie Fondamentale et Clinique, INSERM U503, ENS de Lyon, 69364 Lyon Cedex 07, France. povidala@ens-lyon.fr
Azocar O
Lamouille B
Astier A
Rabourdin-Combe C
Servet-Delprat C
References (15)
15 references, click to expand
  1. TRAIL/Apo-2-ligand-induced apoptosis in human T cells.
    Eur J Immunol. 1998 Jan;28(1):143-52 PMID: 9485194
  2. Identification and characterization of a new member of the TNF family that induces apoptosis.
    Immunity. 1995 Dec;3(6):673-82 PMID: 8777713
  3. Measles virus infection enhances IL-1 beta but reduces tumor necrosis factor-alpha expression in human monocytes.
    J Immunol. 1992 Oct 1;149(7):2397-401 PMID: 1527385
  4. Differential regulation of TRAIL and CD95 ligand in transformed cells of the T and B lymphocyte lineage.
    Eur J Immunol. 1998 Mar;28(3):973-82 PMID: 9541592
  5. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.
    Nat Med. 1999 Feb;5(2):157-63 PMID: 9930862
  6. Measles virus infection induces terminal differentiation of human thymic epithelial cells.
    J Virol. 1999 Mar;73(3):2212-21 PMID: 9971804
  7. Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine, TRAIL.
    J Exp Med. 1999 Apr 19;189(8):1343-54 PMID: 10209050
  8. Mechanism of suppression of cell-mediated immunity by measles virus.
    Science. 1996 Jul 12;273(5272):228-31 PMID: 8662504
  9. Induction of maturation of human blood dendritic cell precursors by measles virus is associated with immunosuppression.
    Proc Natl Acad Sci U S A. 1997 May 13;94(10):5326-31 PMID: 9144236
  10. Measles virus infects human dendritic cells and blocks their allostimulatory properties for CD4+ T cells.
    J Exp Med. 1997 Sep 15;186(6):801-12 PMID: 9294135
  11. Measles virus suppresses cell-mediated immunity by interfering with the survival and functions of dendritic and T cells.
    J Exp Med. 1997 Sep 15;186(6):813-23 PMID: 9294136
  12. Interleukin-1 beta converting enzyme-like protease involvement in Fas-induced and activation-induced peripheral blood T cell apoptosis in HIV infection. TNF-related apoptosis-inducing ligand can mediate activation-induced T cell death in HIV infection.
    J Exp Med. 1997 Oct 20;186(8):1365-72 PMID: 9334376
  13. Effect of measles virus infection on MHC class II expression and antigen presentation in human monocytes.
    Cell Immunol. 1993 Apr 1;147(2):388-96 PMID: 7680965
  14. Direct evidence that interferon-beta mediates enhanced HLA-class I expression in measles virus-infected cells.
    J Immunol. 1993 Dec 1;151(11):6248-58 PMID: 8245464
  15. Characterization of the cytotoxic factor(s) released from thymic dendritic cells upon human immunodeficiency virus type 1 infection.
    Virology. 1998 Feb 15;241(2):285-97 PMID: 9499803
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/jvi.74.1.556-559.2000
Email
povidala@ens-lyon.fr
Published
2000-01-00
Pages
556-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC111571
Subset
IM
External Links
PubMed source DOI: 10.1128/jvi.74.1.556-559.2000 PMC Full Text View journal details
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