Selecting culprits in type 1 diabetes beta-cell killing.

The Journal of clinical investigation ·Vol. 104 ·No. 11 ·1999-12-00 ·Pages 1487-9

Lernmark A

Abstract

暂无摘要

MeSH Terms

Antigen-Presenting Cells/immunology Autoantibodies/analysis Autoantigens Biomarkers/analysis Diabetes Mellitus, Type 1/epidemiology,genetics,immunology Glutamate Decarboxylase/immunology HLA-DR Antigens/immunology HLA-DRB1 Chains Histocompatibility Antigens Class II/immunology Humans Islets of Langerhans/immunology Isoenzymes/immunology Membrane Proteins/immunology Models, Molecular Protein Conformation Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases/immunology Receptor-Like Protein Tyrosine Phosphatases, Class 8

Chemicals

Autoantibodies Autoantigens Biomarkers HLA-DR Antigens HLA-DRB1 Chains Histocompatibility Antigens Class II Isoenzymes Membrane Proteins PTPRN protein, human Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases Receptor-Like Protein Tyrosine Phosphatases, Class 8 Glutamate Decarboxylase glutamate decarboxylase 2

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Lernmark A

References (23)

23 references, click to expand

Association between autoantibody markers and subtypes of DR4 and DR4-DQ in Swedish children with insulin-dependent diabetes reveals closer association of tyrosine pyrophosphatase autoimmunity with DR4 than DQ8.
Tissue Antigens. 1998 Mar;51(3):281-6 PMID: 9550329
Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers.
Diabetes. 1997 Nov;46(11):1701-10 PMID: 9356015
Molecular basis for HLA-DQ associations with IDDM.
Diabetes. 1998 Aug;47(8):1177-84 PMID: 9703314
Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop.
Diabetes. 1998 Dec;47(12):1857-66 PMID: 9836516
Relationship of beta-cell function and autoantibodies to progression and nonprogression of subclinical type 1 diabetes: follow-up of the Seattle Family Study.
Diabetes. 1999 Jan;48(1):170-5 PMID: 9892239
Islet autoantibodies in cord blood from children who developed type I (insulin-dependent) diabetes mellitus before 15 years of age.
Diabetologia. 1999 Feb;42(2):181-7 PMID: 10064098
Negative association between type 1 diabetes and HLA DQB1*0602-DQA1*0102 is attenuated with age at onset. Swedish Childhood Diabetes Study Group.
Eur J Immunogenet. 1999 Apr-Jun;26(2-3):117-27 PMID: 10331157
Differential presentation of glutamic acid decarboxylase 65 (GAD65) T cell epitopes among HLA-DRB1*0401-positive individuals.
J Immunol. 1999 Aug 1;163(3):1674-81 PMID: 10415074
Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus.
J Clin Invest. 1999 Aug;104(4):515-23 PMID: 10449443
Autoreactive T cell responses in insulin-dependent (Type 1) diabetes mellitus. Report of the first international workshop for standardization of T cell assays.
J Autoimmun. 1999 Sep;13(2):267-82 PMID: 10479395
Identification of peptides from autoantigens GAD65 and IA-2 that bind to HLA class II molecules predisposing to or protecting from type 1 diabetes.
Diabetes. 1999 Oct;48(10):1937-47 PMID: 10512357
Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4.
J Clin Invest. 1999 Nov;104(10):1449-57 PMID: 10562307
Incidence of childhood-onset insulin-dependent diabetes mellitus: the EURODIAB ACE Study.
Lancet. 1992 Apr 11;339(8798):905-9 PMID: 1348306
Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus.
J Clin Invest. 1992 Dec;90(6):2242-50 PMID: 1469084
Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity.
Diabetes. 1994 Oct;43(10):1254-9 PMID: 7926297
Insulin-dependent diabetes mellitus as an autoimmune disease.
Endocr Rev. 1994 Aug;15(4):516-42 PMID: 7988484
Immunology in diabetes: an update.
Diabetes Metab Rev. 1998 Mar;14(1):3-29 PMID: 9605628
The Diabetes Prevention Trial-Type 1 diabetes (DPT-1): implementation of screening and staging of relatives. DPT-1 Study Group.
Transplant Proc. 1995 Dec;27(6):3377 PMID: 8540003
Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies.
Diabetes. 1996 Jul;45(7):926-33 PMID: 8666144
Autoantibodies in insulin-dependent diabetes recognize distinct cytoplasmic domains of the protein tyrosine phosphatase-like IA-2 autoantigen.
J Immunol. 1996 Sep 15;157(6):2707-11 PMID: 8805677
Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.
J Clin Invest. 1996 Dec 1;98(11):2597-603 PMID: 8958223
Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients.
J Clin Invest. 1997 May 15;99(10):2405-15 PMID: 9153283
Autoantibodies to IA-2 and IA-2 beta in insulin-dependent diabetes mellitus recognize conformational epitopes: location of the 37- and 40-kDa fragments determined.
J Immunol. 1997 Oct 1;159(7):3662-7 PMID: 9317167

Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI8826

Published

1999-12-00

Pages

1487-9

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC409869

Subset

Corrections

CommentOn

PMID: 10562307

External Links

PubMed source DOI: 10.1172/JCI8826 PMC Full Text View journal details

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