Stimulation of bone formation in vitro and in rodents by statins.

Science (New York, N.Y.) ·Vol. 286 ·No. 5446 ·1999-12-03 ·Pages 1946-9

Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, Boyce B, Zhao M, Gutierrez G

Abstract

Osteoporosis and other diseases of bone loss are a major public health problem. Here it is shown that the statins, drugs widely used for lowering serum cholesterol, also enhance new bone formation in vitro and in rodents. This effect was associated with increased expression of the bone morphogenetic protein-2 (BMP-2) gene in bone cells. Lovastatin and simvastatin increased bone formation when injected subcutaneously over the calvaria of mice and increased cancellous bone volume when orally administered to rats. Thus, in appropriate doses, statins may have therapeutic applications for the treatment of osteoporosis.

MeSH Terms

Animals Bone Density/drug effects Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins/biosynthesis,genetics,pharmacology Cell Line Female Fibroblast Growth Factor 1 Fibroblast Growth Factor 2/pharmacology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology Lovastatin/pharmacology Male Mice Mice, Inbred ICR Organ Culture Techniques Osteoblasts/drug effects,metabolism Osteoclasts/drug effects Osteogenesis/drug effects Osteoporosis/drug therapy Ovariectomy Promoter Regions, Genetic/drug effects Rats Recombinant Proteins/pharmacology Simvastatin/pharmacology Skull Transfection Transforming Growth Factor beta

Chemicals

BMP2 protein, human Bmp2 protein, mouse Bmp2 protein, rat Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins Hydroxymethylglutaryl-CoA Reductase Inhibitors Recombinant Proteins Transforming Growth Factor beta recombinant human bone morphogenetic protein-2 Fibroblast Growth Factor 2 Fibroblast Growth Factor 1 Lovastatin Simvastatin

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Mundy G

OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA. mundy@uthscsa.edu

Garrett R

Harris S

Chan J

Chen D

Rossini G

Boyce B

Zhao M

Gutierrez G

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.286.5446.1946

mundy@uthscsa.edu

Published

1999-12-03

Pages

1946-9

Language

English

Region

United States

NLM ID

0404511

Subset

Corrections

CommentIn

PMID: 10610568

External Links

PubMed source DOI: 10.1126/science.286.5446.1946 View journal details

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Stimulation of bone formation in vitro and in rodents by statins.

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