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PMID: 10574750 Published · ppublish English Journal Article Review

Synapse structure: glutamate receptors connected by the shanks.

Current biology : CB ·Vol. 9 ·No. 22 ·1999-11-18 ·Pages R848-50

Ehlers MD

Abstract

A family of proteins has been identified whose members, the Shanks, physically link two major receptor complexes at excitatory synapses - NMDA receptors and metabotropic glutamate receptors.

MeSH Terms
Adaptor Proteins, Signal Transducing Animals Carrier Proteins/chemistry,genetics,physiology Cortactin Homer Scaffolding Proteins Humans Macromolecular Substances Microfilament Proteins/chemistry,physiology Models, Molecular Models, Neurological Nerve Tissue Proteins/chemistry,genetics,physiology Neuropeptides/chemistry,physiology Protein Structure, Tertiary Receptors, Metabotropic Glutamate/chemistry,physiology Receptors, N-Methyl-D-Aspartate/chemistry,physiology SAP90-PSD95 Associated Proteins Signal Transduction Synapses/chemistry,ultrastructure Two-Hybrid System Techniques
Chemicals
Adaptor Proteins, Signal Transducing Carrier Proteins Cortactin Homer Scaffolding Proteins Macromolecular Substances Microfilament Proteins Nerve Tissue Proteins Neuropeptides Receptors, Metabotropic Glutamate Receptors, N-Methyl-D-Aspartate SAP90-PSD95 Associated Proteins SHANK2 protein, human SHANK3 protein, human Shank1 protein, rat Shank2 protein, rat postsynaptic density proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ehlers M D
Department of Neurobiology, Duke University Medical Center, Durham, 27710, USA. ehlers@neuro.duke.edu
Article Info
Journal
Current biology : CB
Abbr.
Curr Biol
ISSN
0960-9822
Published
1999-11-18
Pages
R848-50
Language
English
Region
England
NLM ID
9107782
Subset
IM
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