Abstract
A family of proteins has been identified whose members, the Shanks, physically link two major receptor complexes at excitatory synapses - NMDA receptors and metabotropic glutamate receptors.
MeSH Terms
Adaptor Proteins, Signal Transducing
Animals
Carrier Proteins/chemistry,genetics,physiology
Cortactin
Homer Scaffolding Proteins
Humans
Macromolecular Substances
Microfilament Proteins/chemistry,physiology
Models, Molecular
Models, Neurological
Nerve Tissue Proteins/chemistry,genetics,physiology
Neuropeptides/chemistry,physiology
Protein Structure, Tertiary
Receptors, Metabotropic Glutamate/chemistry,physiology
Receptors, N-Methyl-D-Aspartate/chemistry,physiology
SAP90-PSD95 Associated Proteins
Signal Transduction
Synapses/chemistry,ultrastructure
Two-Hybrid System Techniques
Chemicals
Adaptor Proteins, Signal Transducing
Carrier Proteins
Cortactin
Homer Scaffolding Proteins
Macromolecular Substances
Microfilament Proteins
Nerve Tissue Proteins
Neuropeptides
Receptors, Metabotropic Glutamate
Receptors, N-Methyl-D-Aspartate
SAP90-PSD95 Associated Proteins
SHANK2 protein, human
SHANK3 protein, human
Shank1 protein, rat
Shank2 protein, rat
postsynaptic density proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ehlers M D
Department of Neurobiology, Duke University Medical Center, Durham, 27710, USA. ehlers@neuro.duke.edu