Adenosine deaminase activity in leukaemia.
Adenosine deaminase (EC 3.5.4.4., ADA) has been measured in the blast cells of 36 patients with acute lymphoblastic, acute myeloid, chronic myeloid and chronic myeloid blast crisis leukaemia. Particularly high levels were found in acute lymphoblastic and chronic myeloid blast crisis patients. The measurement of ADA may be useful diagnostically in the undifferentiated acute leukaemias and in detecting the early onset of blast crisis in chronic myeloid leukaemia. Possible reasons for the elevation of ADA in malignant cells are discussed.
19 references, click to expand
-
Adenosine deaminase.Biochem J. 1942 Jun;36(5-6):478-84 PMID: 16747549
-
The deaminases of adenosine and adenylic acid in blood and tissues.Biochem J. 1939 Apr;33(4):479-92 PMID: 16746934
-
A STUDY OF THE TISSUE DISTRIBUTION OF ADENOSINE DEAMINASE IN SIX MAMMAL SPECIES.Comp Biochem Physiol. 1965 Jan;14:101-20 PMID: 14288190
-
SERUM ADENOSINE DEAMINASE IN THE DIFFERENTIAL DIAGNOSIS OF JAUNDICE.Br Med J. 1965 Feb 6;1(5431):353-5 PMID: 14237902
-
Adenosine deaminase activity in lymphoid cells during antibody production.Aust J Exp Biol Med Sci. 1963 Feb;41:93-7 PMID: 13952110
-
Serum adenosine deaminase: methodology and clinical applications.Clin Chem. 1962 Apr;8:133-40 PMID: 14457664
-
Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity.Lancet. 1972 Nov 18;2(7786):1067-9 PMID: 4117384
-
Adult acute leukaemia.Br J Cancer. 1974 Sep;30(3):272-8 PMID: 4141625
-
Evidence for control of several different tissue-specific isozymes of adenosine deaminase by a single genetic locus.Nat New Biol. 1973 Dec 19;246(155):200-2 PMID: 4519601
-
Multiple forms of human adenosine deaminase. II. Isolation and properties of a conversion factor from human lung.Biochim Biophys Acta. 1973 Apr 12;302(2):429-42 PMID: 4121544
-
Adenosine-deaminase deficiency and combined immunodeficiency syndrome.Lancet. 1972 Dec 16;2(7790):1316 PMID: 4117846
-
The treatment of terminal metamorphosis of chronic granulocytic leukaemia with corticosteroids and vincristine.Acta Haematol. 1973;50(1):1-8 PMID: 4200800
-
Identification of the enzymatic pathways of nucleotide metabolism in human lymphocytes and leukemia cells.Cancer Res. 1973 Jan;33(1):94-103 PMID: 4509125
-
Absence of erythrocyte adenosine deaminase associated with severe combined immunodeficiency.J Pediatr. 1974 Feb;84(2):173-7 PMID: 4810724
-
Lethality of adenosine for cultured mammalian cells by interference with pyrimidine biosynthesis.J Cell Sci. 1973 Sep;13(2):429-39 PMID: 4760594
-
Metabolism of the circulating leukocyte.Physiol Rev. 1965 Oct;45(4):674-720 PMID: 5318995
-
Hematologic and cytogenetic remission of blastic transformation in chronic granulocytic leukemia.Blood. 1971 Dec;38(6):671-9 PMID: 5288508
-
Multienzyme patterns of serum adenosine deaminase by agar gel electrophoresis: an evaluation of the diagnostic value in lung cancer.Clin Chim Acta. 1970 Nov;30(2):251-8 PMID: 5478313
-
Multiple forms of calf serum adenosine deaminase.Arch Biochem Biophys. 1967 Feb;118(2):428-33 PMID: 6033718
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