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PMID: 1054491 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Nonrandom chromosomal abnormalities in hematologic disorders of man.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 1 ·1975-01-00 ·Pages 152-6

Rowley JD

Abstract

A nonrandom pattern of chromosomal abnormalities occurs in bone marrow cells obtained from patients with hematologic disorders who have an abnormal karyotype involving a C group chromosome. An additional number 8 chromosome is the most common abnormality, found in more than one-half of the patients studies. An additional number 9 chromosome and the loss of all or part of a number 7 are abnormalities that occur more often than might be expected by chance. It is proposed that specific human chromosomal abnormalities may be related to different specific etiologic agents.

MeSH Terms
Acute Disease Anemia, Sideroblastic/genetics Bone Marrow Cells Chromosomes, Human, 6-12 and X Hematologic Diseases/genetics Humans Karyotyping Leukemia/genetics Leukemia, Myeloid/genetics Polycythemia Vera/genetics Trisomy
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Rowley J D
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35 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.72.1.152
Published
1975-01-00
Pages
152-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC432260
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.72.1.152 PMC Full Text View journal details
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