Serum ferritin in acute leukaemia at presentation and during remission.

British medical journal ·Vol. 1 ·No. 5952 ·1975-02-01 ·Pages 245-7

Parry DH, Worwood M, Jacobs A

Abstract

In patients with acute myeloblastic leukaemia the mean serum ferritin concentration showed a twenty-five-fold increase compared with normal people, and in children with acute lymphoblastic leukaemia (A.L.L.) there was a thirteen-fold increase. The high concentration of circulating ferritin seemed to be related to increased synthesis by leukaemic cells. The return of serum concentrations to normal in A.L.L. patients after successful chemotherapy suggested that ferritin concentration may be a useful index of active disease and may help in prognosis.

MeSH Terms

Adolescent Alanine Transaminase/blood Aspartate Aminotransferases/blood Binding Sites Child Child, Preschool Ferritins/analysis Hemoglobins Humans Infant Iron/blood Leukemia, Lymphoid/blood,drug therapy Leukemia, Myeloid, Acute/blood,drug therapy Leukocyte Count Prognosis Radioimmunoassay

Chemicals

Hemoglobins Ferritins Iron Aspartate Aminotransferases Alanine Transaminase

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Parry D H

Worwood M

Jacobs A

References (6)

6 references, click to expand

Ferritin synthesis in normal and leukaemic leukocytes.
Nature. 1974 Aug 16;250(467):584-6 PMID: 4526613
Ferritin in serum: diagnosis of iron deficiency and iron overload in infants and children.
Blood. 1974 Apr;43(4):581-90 PMID: 4522154
Five-year follow-up of "total therapy" of childhood lymphocytic leukemia.
JAMA. 1971 Apr 26;216(4):648-52 PMID: 5279904
Ferritin in normal erythrocytes, lymphocytes, polymorphs, and monocytes.
Br J Haematol. 1974 Sep;28(1):19-26 PMID: 4413456
Serum ferritin concentration and iron stores in normal subjects.
J Clin Pathol. 1973 Oct;26(10):770-2 PMID: 4750458
Ferritin in blood cells from normal subjects and patients with leukaemia.
Br J Haematol. 1974 Sep;28(1):27-35 PMID: 4528565

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.1.5952.245

Published

1975-02-01

Pages

245-7

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1672022

Subset

External Links

PubMed source DOI: 10.1136/bmj.1.5952.245 PMC Full Text

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Serum ferritin in acute leukaemia at presentation and during remission.

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